Silencing of hypoxia-inducible factor-1β induces anti-tumor effects in hepatoma cell lines under tumor hypoxia.

Silencing of hypoxia-inducible factor-1β induces anti-tumor effects in hepatoma cell lines under tumor hypoxia.

Dimerization of hypoxia-inducible factor-1 beta (HIF-1β) [aryl hydrocarbon receptor nuclear translocator (ARNT)] with HIF-1α is involved in various aspects of cancer biology, including proliferation and survival under hypoxic conditions. We investigated the in vitro mechanism by which silencing of H...

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Bibliographic Details
Main Authors: Sung Hoon Choi, Ae Ri Chung, Wonseok Kang, Jun Yong Park, Mi Sol Lee, Shin Won Hwang, Do Young Kim, Seung Up Kim, Sang Hoon Ahn, Seungtaek Kim, Kwang-Hyub Han
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103304&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103304&type=printable

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