Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study
Objectives Autoimmune rheumatic diseases (ARDs) affect women of childbearing age and have been associated with adverse birth outcomes. The impact of diseases like ankylosing spondylitis and psoriatic arthritis (PsA) on birth outcomes remains less studied to date. Our objective was to evaluate the im...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-05-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/5/1/e000878.full |
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| author | Nisha Parikh Jennifer Strouse Brittney M Donovan Munazza Fatima Ruth Fernandez-Ruiz Rebecca J Baer Nichole Nidey Chelsey Forbess Gretchen Bandoli Randi Paynter Laura Jeliffe-Pawlowski Kelli K Ryckman Namrata Singh |
| author_facet | Nisha Parikh Jennifer Strouse Brittney M Donovan Munazza Fatima Ruth Fernandez-Ruiz Rebecca J Baer Nichole Nidey Chelsey Forbess Gretchen Bandoli Randi Paynter Laura Jeliffe-Pawlowski Kelli K Ryckman Namrata Singh |
| author_sort | Nisha Parikh |
| collection | DOAJ |
| description | Objectives Autoimmune rheumatic diseases (ARDs) affect women of childbearing age and have been associated with adverse birth outcomes. The impact of diseases like ankylosing spondylitis and psoriatic arthritis (PsA) on birth outcomes remains less studied to date. Our objective was to evaluate the impact of ARDs on preterm birth (PTB), congenital anomalies, low birth weight (LBW) and small for gestational age (SGA), in a large cohort of women.Methods We conducted a propensity score-matched analysis to predict ARD from a retrospective birth cohort of all live, singleton births in California occurring between 2007 and 2012. Data were derived from birth certificate records linked to hospital discharge International Classification of Diseases, ninth revision codes.Results We matched 10 244 women with a recorded ARD diagnosis (rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome, PsA); ankylosing spondylitis and juvenile idiopathic arthritis (JIA) to those without an ARD diagnosis. The adjusted OR (aOR) of PTB was increased for women with any ARD (aOR 1.93, 95% CI 1.78 to 2.10) and remained significant for those with RA, SLE, PsA and JIA. The odds of LBW and SGA were also significantly increased among women with an ARD diagnosis. ARDs were not associated with increased odds of congenital anomalies.Conclusion Consistent with prior literature, we found that women with ARDs are more likely to have PTB or deliver an SGA infant. Some reassurance is provided that an increase in congenital anomalies was not found even in this large cohort. |
| format | Article |
| id | doaj-art-9c4707887b4d4e86ae4651330045d316 |
| institution | OA Journals |
| issn | 2056-5933 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-9c4707887b4d4e86ae4651330045d3162025-08-20T02:39:03ZengBMJ Publishing GroupRMD Open2056-59332019-05-015110.1136/rmdopen-2018-000878Impact of autoimmune rheumatic diseases on birth outcomes: a population-based studyNisha Parikh0Jennifer Strouse1Brittney M Donovan2Munazza Fatima3Ruth Fernandez-Ruiz4Rebecca J Baer5Nichole Nidey6Chelsey Forbess7Gretchen Bandoli8Randi Paynter9Laura Jeliffe-Pawlowski10Kelli K Ryckman11Namrata Singh12Internal Medicine, Div of Cardiology, University of California San Francisco School of Medicine, San Francisco, California, USAInternal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAInternal Medicine, Vanderbilty University Medical Center, Iowa City, Iowa, USAInternal Medicine, Iowa City VA Medical Center, Iowa City, Iowa, USAInternal Medicine, NYU Langone Health, New York, New York, USAPediatrics, University of California San Diego Health System, San Diego, California, USAEpidemiology, University of Iowa, Iowa City, Iowa, USAInternal Medicine, Harbor-UCLA Medical Center, Torrance, California, USAPediatrics, University of California San Diego Health System, San Diego, California, USAEpidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California, USAEpidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California, USAEpidemiology, University of Iowa, Iowa City, Iowa, USARheumatology, Iowa City VA Medical Center, Iowa City, Iowa, USAObjectives Autoimmune rheumatic diseases (ARDs) affect women of childbearing age and have been associated with adverse birth outcomes. The impact of diseases like ankylosing spondylitis and psoriatic arthritis (PsA) on birth outcomes remains less studied to date. Our objective was to evaluate the impact of ARDs on preterm birth (PTB), congenital anomalies, low birth weight (LBW) and small for gestational age (SGA), in a large cohort of women.Methods We conducted a propensity score-matched analysis to predict ARD from a retrospective birth cohort of all live, singleton births in California occurring between 2007 and 2012. Data were derived from birth certificate records linked to hospital discharge International Classification of Diseases, ninth revision codes.Results We matched 10 244 women with a recorded ARD diagnosis (rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome, PsA); ankylosing spondylitis and juvenile idiopathic arthritis (JIA) to those without an ARD diagnosis. The adjusted OR (aOR) of PTB was increased for women with any ARD (aOR 1.93, 95% CI 1.78 to 2.10) and remained significant for those with RA, SLE, PsA and JIA. The odds of LBW and SGA were also significantly increased among women with an ARD diagnosis. ARDs were not associated with increased odds of congenital anomalies.Conclusion Consistent with prior literature, we found that women with ARDs are more likely to have PTB or deliver an SGA infant. Some reassurance is provided that an increase in congenital anomalies was not found even in this large cohort.https://rmdopen.bmj.com/content/5/1/e000878.full |
| spellingShingle | Nisha Parikh Jennifer Strouse Brittney M Donovan Munazza Fatima Ruth Fernandez-Ruiz Rebecca J Baer Nichole Nidey Chelsey Forbess Gretchen Bandoli Randi Paynter Laura Jeliffe-Pawlowski Kelli K Ryckman Namrata Singh Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study RMD Open |
| title | Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study |
| title_full | Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study |
| title_fullStr | Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study |
| title_full_unstemmed | Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study |
| title_short | Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study |
| title_sort | impact of autoimmune rheumatic diseases on birth outcomes a population based study |
| url | https://rmdopen.bmj.com/content/5/1/e000878.full |
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