Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis
Aim: Whether house dust mite (HDM) sublingual immunotherapy (SLIT) is effective for the skin symptoms of adult atopic dermatitis (AD) is unclear.Methods: HDM SLIT was added to conventional AD treatment for 10 HDM-sensitized AD patients with rhinitis for 2 years.Results: Seven out of ten enrolled pat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2024.2419779 |
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| author | Mayuko Mizuno Shinya Imamura Ai Yoshioka Ken Washio Yoshiko Oda Hiroki Matsuhara Katsuyo Ohashi-Doi Atsushi Fukunaga |
| author_facet | Mayuko Mizuno Shinya Imamura Ai Yoshioka Ken Washio Yoshiko Oda Hiroki Matsuhara Katsuyo Ohashi-Doi Atsushi Fukunaga |
| author_sort | Mayuko Mizuno |
| collection | DOAJ |
| description | Aim: Whether house dust mite (HDM) sublingual immunotherapy (SLIT) is effective for the skin symptoms of adult atopic dermatitis (AD) is unclear.Methods: HDM SLIT was added to conventional AD treatment for 10 HDM-sensitized AD patients with rhinitis for 2 years.Results: Seven out of ten enrolled patients completed the study. Eczema Area and Severity Index score was significantly reduced when comparing before treatment and at 24 months follow-up. CD203c ratio in the basophil activation test using HDM extract, skin prick test with HDM extract and Dermatophagoides pteronyssinus/Dermatophagoides farinae specific-IgG4 tended to improve when comparing before treatment and after treatment.Conclusion: HDM SLIT might be a therapeutic option for AD patients with rhinitis who are sensitized to HDM. |
| format | Article |
| id | doaj-art-9c3fc170e0694dd39dac94e83bd90024 |
| institution | Kabale University |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-9c3fc170e0694dd39dac94e83bd900242025-08-20T03:50:39ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.1080/20565623.2024.2419779Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitisMayuko Mizuno0Shinya Imamura1Ai Yoshioka2Ken Washio3Yoshiko Oda4Hiroki Matsuhara5Katsuyo Ohashi-Doi6Atsushi Fukunaga7Department of Internal Related, Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, JapanDepartment of Internal Related, Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, JapanDepartment of Internal Related, Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, JapanDepartment of Internal Related, Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, JapanDepartment of Internal Related, Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, JapanTorii Pharmaceutical Co., Ltd, 3-4-1, Nihonbashi-Honcho, Chuo-Ku, Tokyo, 103-8439, JapanTorii Pharmaceutical Co., Ltd, 3-4-1, Nihonbashi-Honcho, Chuo-Ku, Tokyo, 103-8439, JapanDepartment of Internal Related, Division of Dermatology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, JapanAim: Whether house dust mite (HDM) sublingual immunotherapy (SLIT) is effective for the skin symptoms of adult atopic dermatitis (AD) is unclear.Methods: HDM SLIT was added to conventional AD treatment for 10 HDM-sensitized AD patients with rhinitis for 2 years.Results: Seven out of ten enrolled patients completed the study. Eczema Area and Severity Index score was significantly reduced when comparing before treatment and at 24 months follow-up. CD203c ratio in the basophil activation test using HDM extract, skin prick test with HDM extract and Dermatophagoides pteronyssinus/Dermatophagoides farinae specific-IgG4 tended to improve when comparing before treatment and after treatment.Conclusion: HDM SLIT might be a therapeutic option for AD patients with rhinitis who are sensitized to HDM.https://www.tandfonline.com/doi/10.1080/20565623.2024.2419779allergy immunotherapyatopic dermatitisdermatophagoides farinaedermatophagoides pteronyssinussublingual immunotherapy |
| spellingShingle | Mayuko Mizuno Shinya Imamura Ai Yoshioka Ken Washio Yoshiko Oda Hiroki Matsuhara Katsuyo Ohashi-Doi Atsushi Fukunaga Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis Future Science OA allergy immunotherapy atopic dermatitis dermatophagoides farinae dermatophagoides pteronyssinus sublingual immunotherapy |
| title | Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis |
| title_full | Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis |
| title_fullStr | Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis |
| title_full_unstemmed | Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis |
| title_short | Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis |
| title_sort | effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis |
| topic | allergy immunotherapy atopic dermatitis dermatophagoides farinae dermatophagoides pteronyssinus sublingual immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2024.2419779 |
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