Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications
Stimuli-responsive, or “smart”, injectable hydrogels respond to real-time stimuli through physical or chemical changes. This allows hydrogels to be dynamic within their environment in the presence of internal or external stimuli. Owing to this, smart injectable hydrogels have gained noticeable impli...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Biomaterials Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbiom.2025.1641339/full |
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| author | Abdulla Al Mamun Yasmeen Shamiya Anwarul Hasan Anwarul Hasan Anwarul Hasan Arghya Paul Arghya Paul |
| author_facet | Abdulla Al Mamun Yasmeen Shamiya Anwarul Hasan Anwarul Hasan Anwarul Hasan Arghya Paul Arghya Paul |
| author_sort | Abdulla Al Mamun |
| collection | DOAJ |
| description | Stimuli-responsive, or “smart”, injectable hydrogels respond to real-time stimuli through physical or chemical changes. This allows hydrogels to be dynamic within their environment in the presence of internal or external stimuli. Owing to this, smart injectable hydrogels have gained noticeable implications within the field of biomedicine. Over the past decade, stimuli-responsive injectable hydrogels have been extensively studied for wound healing and cancer therapies but remain largely unexplored for bone healing applications. In this mini-review, we aim to explore the role of smart injectable hydrogels and assess their current and future implications within the field of bone healing. Specifically, we discuss the physicochemical and biological aspects that must be taken into consideration when developing a material in this field, as well as the various strategies for designing such a material. Additionally, we discuss the current role of stimuli-responsive injectable hydrogels for an array of bone healing applications and their potential for successful clinical translation. |
| format | Article |
| id | doaj-art-9c3cdbd759d44b449834a89ab7774369 |
| institution | Kabale University |
| issn | 2813-3749 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Biomaterials Science |
| spelling | doaj-art-9c3cdbd759d44b449834a89ab77743692025-08-20T03:36:38ZengFrontiers Media S.A.Frontiers in Biomaterials Science2813-37492025-08-01410.3389/fbiom.2025.16413391641339Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applicationsAbdulla Al Mamun0Yasmeen Shamiya1Anwarul Hasan2Anwarul Hasan3Anwarul Hasan4Arghya Paul5Arghya Paul6Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON, CanadaDepartment of Chemistry, The University of Western Ontario, London, ON, CanadaDepartment of Bioengineering, King Fahd University of Petroleum and Minerals, Dhahran, Saudi ArabiaInterdisciplinary Research Center for Bio Systems and Machines, King Fahd University of Petroleum & Minerals, Dhahran, Saudi ArabiaDepartment of Mechanical and Industrial Engineering, Qatar University, Doha, QatarDepartment of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON, CanadaDepartment of Chemistry, The University of Western Ontario, London, ON, CanadaStimuli-responsive, or “smart”, injectable hydrogels respond to real-time stimuli through physical or chemical changes. This allows hydrogels to be dynamic within their environment in the presence of internal or external stimuli. Owing to this, smart injectable hydrogels have gained noticeable implications within the field of biomedicine. Over the past decade, stimuli-responsive injectable hydrogels have been extensively studied for wound healing and cancer therapies but remain largely unexplored for bone healing applications. In this mini-review, we aim to explore the role of smart injectable hydrogels and assess their current and future implications within the field of bone healing. Specifically, we discuss the physicochemical and biological aspects that must be taken into consideration when developing a material in this field, as well as the various strategies for designing such a material. Additionally, we discuss the current role of stimuli-responsive injectable hydrogels for an array of bone healing applications and their potential for successful clinical translation.https://www.frontiersin.org/articles/10.3389/fbiom.2025.1641339/fullstimuli-responsiveinjectablehydrogelsbone healingbiomaterials |
| spellingShingle | Abdulla Al Mamun Yasmeen Shamiya Anwarul Hasan Anwarul Hasan Anwarul Hasan Arghya Paul Arghya Paul Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications Frontiers in Biomaterials Science stimuli-responsive injectable hydrogels bone healing biomaterials |
| title | Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications |
| title_full | Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications |
| title_fullStr | Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications |
| title_full_unstemmed | Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications |
| title_short | Unlocking the potential of stimuli-responsive injectable hydrogels for bone healing applications |
| title_sort | unlocking the potential of stimuli responsive injectable hydrogels for bone healing applications |
| topic | stimuli-responsive injectable hydrogels bone healing biomaterials |
| url | https://www.frontiersin.org/articles/10.3389/fbiom.2025.1641339/full |
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