3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction
Abstract Porous calcium phosphate ceramics have attracted widespread attention owing to their excellent bioactivity. However, their poor mechanical properties severely limit their clinical applications. Significantly improving the mechanical strength of porous CaP ceramics while maintaining their bi...
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202408459 |
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| author | Boqing Zhang Kaixin Wang Xingyu Gui Wenzhao Wang Ping Song Lina Wu Likun Guo Changchun Zhou Yujiang Fan Xingdong Zhang |
| author_facet | Boqing Zhang Kaixin Wang Xingyu Gui Wenzhao Wang Ping Song Lina Wu Likun Guo Changchun Zhou Yujiang Fan Xingdong Zhang |
| author_sort | Boqing Zhang |
| collection | DOAJ |
| description | Abstract Porous calcium phosphate ceramics have attracted widespread attention owing to their excellent bioactivity. However, their poor mechanical properties severely limit their clinical applications. Significantly improving the mechanical strength of porous CaP ceramics while maintaining their bioactivity remains a major challenge. To address this issue, calcium sulfate is used to regulate the directional growth of hydroxyapatite grains during ceramic sintering. The in situ oriented grains can not only alleviate the stress concentration but also strengthen the bonding force between the ceramic grain boundaries. Calcium sulfate improves the release of active calcium ions from calcium phosphate ceramics, further enhancing their bioactivity and osteoinductivity in vivo. Transcriptome and proteome sequencing reveals that the in situ whisker‐reinforced ceramics increase the expression of proteins related to calcium ion binding and promote the expression of osteogenesis‐related proteins. In the supercritical bone defect repair model, repair of the defect is achieved within 3 months, with mechanical recovery reaching more than 70% of the autologous bone. |
| format | Article |
| id | doaj-art-9c3938fe40b24daa946862654707da0e |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-9c3938fe40b24daa946862654707da0e2025-01-13T15:29:43ZengWileyAdvanced Science2198-38442025-01-01122n/an/a10.1002/advs.2024084593D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect ReconstructionBoqing Zhang0Kaixin Wang1Xingyu Gui2Wenzhao Wang3Ping Song4Lina Wu5Likun Guo6Changchun Zhou7Yujiang Fan8Xingdong Zhang9National Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaNational Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaNational Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaDepartment of Orthopedics Qilu Hospital of Shandong University 107 Wenhua Road Jinan 250000 P. R. ChinaDepartment of Orthopedics Orthopedic Research Institute West China Hospital Sichuan University 37 Guoxue Road Chengdu 610041 P. R. ChinaNational Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaNational Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaNational Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaNational Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaNational Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. ChinaAbstract Porous calcium phosphate ceramics have attracted widespread attention owing to their excellent bioactivity. However, their poor mechanical properties severely limit their clinical applications. Significantly improving the mechanical strength of porous CaP ceramics while maintaining their bioactivity remains a major challenge. To address this issue, calcium sulfate is used to regulate the directional growth of hydroxyapatite grains during ceramic sintering. The in situ oriented grains can not only alleviate the stress concentration but also strengthen the bonding force between the ceramic grain boundaries. Calcium sulfate improves the release of active calcium ions from calcium phosphate ceramics, further enhancing their bioactivity and osteoinductivity in vivo. Transcriptome and proteome sequencing reveals that the in situ whisker‐reinforced ceramics increase the expression of proteins related to calcium ion binding and promote the expression of osteogenesis‐related proteins. In the supercritical bone defect repair model, repair of the defect is achieved within 3 months, with mechanical recovery reaching more than 70% of the autologous bone.https://doi.org/10.1002/advs.202408459bioceramicgrain growth regulationmechanical enhancementosteoinduction supercritical bone defect |
| spellingShingle | Boqing Zhang Kaixin Wang Xingyu Gui Wenzhao Wang Ping Song Lina Wu Likun Guo Changchun Zhou Yujiang Fan Xingdong Zhang 3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction Advanced Science bioceramic grain growth regulation mechanical enhancement osteoinduction supercritical bone defect |
| title | 3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction |
| title_full | 3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction |
| title_fullStr | 3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction |
| title_full_unstemmed | 3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction |
| title_short | 3D‐Printed Bioceramic Scaffolds Reinforced by the In Situ Oriented Growth of Grains for Supercritical Bone Defect Reconstruction |
| title_sort | 3d printed bioceramic scaffolds reinforced by the in situ oriented growth of grains for supercritical bone defect reconstruction |
| topic | bioceramic grain growth regulation mechanical enhancement osteoinduction supercritical bone defect |
| url | https://doi.org/10.1002/advs.202408459 |
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