Identification of loci of functional relevance to Barrett's esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative trait loci data from disease-relevant tissues with genetic association data.

Identification of loci of functional relevance to Barrett's esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative trait loci data from disease-relevant tissues with genetic association data.

Esophageal adenocarcinoma (EA) and its precancerous condition Barrett's esophagus (BE) are multifactorial diseases with rising prevalence rates in Western populations. A recent meta-analysis of genome-wide association studies (GWAS) data identified 14 BE/EA risk loci located in non-coding genom...

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Main Authors: Julia Schröder, Vitalia Schüller, Andrea May, Christian Gerges, Mario Anders, Jessica Becker, Timo Hess, Nicole Kreuser, René Thieme, Kerstin U Ludwig, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Claudia Fuchs, Jakob R Izbicki, Arnulf H Hölscher, Dani Dakkak, Boris Jansen-Winkeln, Yusef Moulla, Orestis Lyros, Stefan Niebisch, Matthias Mehdorn, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Rupert Mayershofer, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Elisabeth Mangold, Markus M Nöthen, Susanne Moebus, Michael Knapp, Horst Neuhaus, Thomas Rösch, Christian Ell, Ines Gockel, Johannes Schumacher, Anne C Böhmer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0227072
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