Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals
Chikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients. This study was performed to evaluate the clinical course of the infection in 168 patients with a...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/2071325 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849399786148462592 |
|---|---|
| author | Carlos A. A. de Brito Claudia D. L. Marques Rafael F. O. França Janaína R. Monteiro Marina C. M. de Brito Fabiana Lopes Anton Lima Gabriel L. Marques Maria Luisa Valadares Angela L. B. P. Duarte |
| author_facet | Carlos A. A. de Brito Claudia D. L. Marques Rafael F. O. França Janaína R. Monteiro Marina C. M. de Brito Fabiana Lopes Anton Lima Gabriel L. Marques Maria Luisa Valadares Angela L. B. P. Duarte |
| author_sort | Carlos A. A. de Brito |
| collection | DOAJ |
| description | Chikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients. This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls. Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls (p=0.79). Of those with positive serology, 32 (76%) and 14 (93%) were symptomatic among subjects in the bDMARD and control groups, respectively (p=0.87). Persistence of musculoskeletal symptoms for more than three months occurred in 64% of the patients in the control group and only in 28% in the bDMARD group (p=0.021), maintaining a statistically significant difference only for users of anti-TNF. This study found that patients affected by chikungunya fever using bDMARDs did not present severe forms or complications in the acute phase of the disease, and patients using anti-TNF biologicals had a lower frequency of chronic joint symptoms than the household controls. This favorable outcome may be related to the cytokine blockade, with a reduction in the inflammatory response and joint damage. |
| format | Article |
| id | doaj-art-9c2490eec0534d63be28aaaf0115685f |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-9c2490eec0534d63be28aaaf0115685f2025-08-20T03:38:15ZengWileyJournal of Tropical Medicine1687-96861687-96942020-01-01202010.1155/2020/20713252071325Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with BiologicalsCarlos A. A. de Brito0Claudia D. L. Marques1Rafael F. O. França2Janaína R. Monteiro3Marina C. M. de Brito4Fabiana Lopes5Anton Lima6Gabriel L. Marques7Maria Luisa Valadares8Angela L. B. P. Duarte9Internal Medicine, Clinical Hospital of Federal University of Pernambuco and Autoimmune Institute, Recife, Pernambuco, BrazilRheumatology Service, Clinical Hospital of Federal University of Pernambuco, Recife, Pernambuco, BrazilDepartment of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Pernambuco, BrazilFederal University of Pernambuco, Recife, Pernambuco, BrazilFederal University of Pernambuco, Recife, Pernambuco, BrazilFederal University of Pernambuco, Recife, Pernambuco, BrazilFederal University of Pernambuco, Recife, Pernambuco, BrazilUniversidade Católica de Pernambuco (UNICAP), Recife, Pernambuco, BrazilFaculdade de Medicina de Olinda (FMO), Olinda, Pernambuco, BrazilRheumatology Service, Clinical Hospital of Federal University of Pernambuco, Recife, Pernambuco, BrazilChikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients. This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls. Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls (p=0.79). Of those with positive serology, 32 (76%) and 14 (93%) were symptomatic among subjects in the bDMARD and control groups, respectively (p=0.87). Persistence of musculoskeletal symptoms for more than three months occurred in 64% of the patients in the control group and only in 28% in the bDMARD group (p=0.021), maintaining a statistically significant difference only for users of anti-TNF. This study found that patients affected by chikungunya fever using bDMARDs did not present severe forms or complications in the acute phase of the disease, and patients using anti-TNF biologicals had a lower frequency of chronic joint symptoms than the household controls. This favorable outcome may be related to the cytokine blockade, with a reduction in the inflammatory response and joint damage.http://dx.doi.org/10.1155/2020/2071325 |
| spellingShingle | Carlos A. A. de Brito Claudia D. L. Marques Rafael F. O. França Janaína R. Monteiro Marina C. M. de Brito Fabiana Lopes Anton Lima Gabriel L. Marques Maria Luisa Valadares Angela L. B. P. Duarte Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals Journal of Tropical Medicine |
| title | Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals |
| title_full | Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals |
| title_fullStr | Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals |
| title_full_unstemmed | Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals |
| title_short | Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals |
| title_sort | reduced duration of postchikungunya musculoskeletal pain in rheumatological patients treated with biologicals |
| url | http://dx.doi.org/10.1155/2020/2071325 |
| work_keys_str_mv | AT carlosaadebrito reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT claudiadlmarques reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT rafaelfofranca reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT janainarmonteiro reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT marinacmdebrito reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT fabianalopes reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT antonlima reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT gabriellmarques reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT marialuisavaladares reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals AT angelalbpduarte reduceddurationofpostchikungunyamusculoskeletalpaininrheumatologicalpatientstreatedwithbiologicals |