The role of the Notch signaling pathway in rhabdomyosarcomas
Rhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with poor prognosis in cases of metastasis. Different signal transduction pathways have been studied in RMS cells as to shed some light into the tumorigenesis and metastasis mechanisms of this cancer in the search for new diagnostic and therap...
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| Format: | Article |
| Language: | English |
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Medical University of Gdańsk
2025-07-01
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| Series: | European Journal of Translational and Clinical Medicine |
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| Online Access: | https://ejtcm.gumed.edu.pl/articles/202612.pdf |
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| _version_ | 1849691284779827200 |
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| author | Datis Kalali Emilija Milošević Doxakis Anestakis Doxakis Anestakis |
| author_facet | Datis Kalali Emilija Milošević Doxakis Anestakis Doxakis Anestakis |
| author_sort | Datis Kalali |
| collection | DOAJ |
| description | Rhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with poor prognosis in cases of metastasis. Different signal transduction pathways have been studied in RMS cells as to shed some light into the tumorigenesis and metastasis mechanisms of this cancer in the search for new diagnostic and therapeutic strategies. The Notch pathway, which regulates cell survival, is widely studied in different cancers, including sarcomas and its activation has been known to induce cell motility. To this end, the present review explores the role of the Notch signaling pathway in the progression of RMS and in potential therapeutic strategies. |
| format | Article |
| id | doaj-art-9c2400a70d1a466dab07e1b816e93062 |
| institution | DOAJ |
| issn | 2657-3148 2657-3156 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Medical University of Gdańsk |
| record_format | Article |
| series | European Journal of Translational and Clinical Medicine |
| spelling | doaj-art-9c2400a70d1a466dab07e1b816e930622025-08-20T03:21:06ZengMedical University of GdańskEuropean Journal of Translational and Clinical Medicine2657-31482657-31562025-07-018197102202612The role of the Notch signaling pathway in rhabdomyosarcomasDatis Kalali0https://orcid.org/0000-0002-7345-1692Emilija Milošević1https://orcid.org/0000-0002-0026-1871Doxakis Anestakis2https://orcid.org/0000-0001-8004-7666Doxakis Anestakis3https://orcid.org/0000-0001-8004-7666Medical School, University of Cyprus, Nicosia, CyprusInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, SerbiaMedical School, University of Cyprus, Nicosia, CyprusLaboratory of Autopsy Pathology, Forensic Service of Thessaloniki, Ministry of Justice, Thessaloniki, GreeceRhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with poor prognosis in cases of metastasis. Different signal transduction pathways have been studied in RMS cells as to shed some light into the tumorigenesis and metastasis mechanisms of this cancer in the search for new diagnostic and therapeutic strategies. The Notch pathway, which regulates cell survival, is widely studied in different cancers, including sarcomas and its activation has been known to induce cell motility. To this end, the present review explores the role of the Notch signaling pathway in the progression of RMS and in potential therapeutic strategies.https://ejtcm.gumed.edu.pl/articles/202612.pdfrhabdomyosarcomapediatric sarcomasnotch signalingsignal transduction pathways |
| spellingShingle | Datis Kalali Emilija Milošević Doxakis Anestakis Doxakis Anestakis The role of the Notch signaling pathway in rhabdomyosarcomas European Journal of Translational and Clinical Medicine rhabdomyosarcoma pediatric sarcomas notch signaling signal transduction pathways |
| title | The role of the Notch signaling pathway in rhabdomyosarcomas |
| title_full | The role of the Notch signaling pathway in rhabdomyosarcomas |
| title_fullStr | The role of the Notch signaling pathway in rhabdomyosarcomas |
| title_full_unstemmed | The role of the Notch signaling pathway in rhabdomyosarcomas |
| title_short | The role of the Notch signaling pathway in rhabdomyosarcomas |
| title_sort | role of the notch signaling pathway in rhabdomyosarcomas |
| topic | rhabdomyosarcoma pediatric sarcomas notch signaling signal transduction pathways |
| url | https://ejtcm.gumed.edu.pl/articles/202612.pdf |
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