Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases
The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2021/6632719 |
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| _version_ | 1850171428752588800 |
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| author | Xingyun Xu Zhigang Miao Miao Sun Bo Wan |
| author_facet | Xingyun Xu Zhigang Miao Miao Sun Bo Wan |
| author_sort | Xingyun Xu |
| collection | DOAJ |
| description | The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved. |
| format | Article |
| id | doaj-art-9c22b5bcbee54a92aa2c57f80b2644d8 |
| institution | OA Journals |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-9c22b5bcbee54a92aa2c57f80b2644d82025-08-20T02:20:16ZengWileyInternational Journal of Genomics2314-436X2314-43782021-01-01202110.1155/2021/66327196632719Epigenetic Mechanisms of Paternal Stress in Offspring Development and DiseasesXingyun Xu0Zhigang Miao1Miao Sun2Bo Wan3Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou City, ChinaInstitute of Neuroscience, Soochow University, Suzhou City, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou City, ChinaInstitute of Neuroscience, Soochow University, Suzhou City, ChinaThe major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. Sperm has a unique epigenome. An increasing body of epidemiological study supports that paternal stress induced by environmental exposures and lifestyle can modulate the sperm epigenome (including histone modification, DNA methylation, and noncoding RNA expression), sperm-egg fusion, embryo development, and offspring health. Based on the existing literature, we have summarized the paternal exposure on sperm epigenome along with the representative phenotypes of offspring and the possible mechanism involved.http://dx.doi.org/10.1155/2021/6632719 |
| spellingShingle | Xingyun Xu Zhigang Miao Miao Sun Bo Wan Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases International Journal of Genomics |
| title | Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases |
| title_full | Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases |
| title_fullStr | Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases |
| title_full_unstemmed | Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases |
| title_short | Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases |
| title_sort | epigenetic mechanisms of paternal stress in offspring development and diseases |
| url | http://dx.doi.org/10.1155/2021/6632719 |
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