Diverse Lenabasum pathway activation in dermatomyositis patients’ blood

Diverse Lenabasum pathway activation in dermatomyositis patients’ blood

Abstract Lenabasum, a non-psychoactive cannabinoid type-2 receptor (CB2R) agonist, has shown promise in reducing cutaneous disease in Dermatomyositis (DM) patients. Lenabasum activates two distinct receptors: CB2R and the nuclear peroxisome proliferator-activated receptor-γ (PPARγ). Our goal was to...

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Bibliographic Details
Main Authors: Nilesh Kodali, DeAnna Diaz, Rohan Dhiman, Thomas Vazquez, Rui Feng, Jay Patel, Joshua Dan, Grant Sprow, Julianne Kleitsch, Meena Sharma, Muhammad Bashir, Victoria P. Werth
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Dermatomyositis
Lenabasum
IFNβ
Flow cytometry
Mechanism
Online Access:https://doi.org/10.1038/s41598-025-92001-z
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