CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner

CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner

Abstract The maintenance of intestinal homeostasis is a fundamental process critical for organismal integrity. Sitting at the interface of the gut microbiome and mucosal immunity, adaptive and innate lymphoid populations regulate the balance between commensal micro-organisms and pathogens. Checkpoin...

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Main Authors: Jonathan W. Lo, Jan-Hendrik Schroeder, Luke B. Roberts, Rami Mohamed, Domenico Cozzetto, Gordon Beattie, Omer S. Omer, Ellen M. Ross, Frank Heuts, Geraldine M. Jowett, Emily Read, Matthew Madgwick, Joana F. Neves, Tamas Korcsmaros, Richard G. Jenner, Lucy S. K. Walker, Nick Powell, Graham M. Lord
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51719-6
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