Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential
Scorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases. This review provides a comprehensive analysis of scorpion venom peptides, focusing on thei...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/17/3/114 |
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| author | Kaiyun Xin Ruize Sun Wanyang Xiao Weijie Lu Chenhui Sun Jietao Lou Yanyan Xu Tianbao Chen Di Wu Yitian Gao |
| author_facet | Kaiyun Xin Ruize Sun Wanyang Xiao Weijie Lu Chenhui Sun Jietao Lou Yanyan Xu Tianbao Chen Di Wu Yitian Gao |
| author_sort | Kaiyun Xin |
| collection | DOAJ |
| description | Scorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases. This review provides a comprehensive analysis of scorpion venom peptides, focusing on their roles as voltage-gated sodium (Nav), potassium (Kv), and calcium (Cav) channel modulators. It analyzed Nav1.7 inhibition for analgesia, Kv1.3 blockade for anticancer activity, and membrane disruption for antimicrobial effects. While the low targeting specificity and high toxicity of some scorpion venom peptides pose challenges to their clinical application, recent research has made strides in overcoming these limitations. This review summarizes the latest progress in scorpion venom peptide research, discussing their mechanisms of action, therapeutic potential, and challenges in clinical translation. This work aims to provide new insights and directions for the development of novel therapeutic drugs. |
| format | Article |
| id | doaj-art-9c14e8e293424a059337f6061e37d39c |
| institution | DOAJ |
| issn | 2072-6651 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj-art-9c14e8e293424a059337f6061e37d39c2025-08-20T02:43:09ZengMDPI AGToxins2072-66512025-02-0117311410.3390/toxins17030114Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic PotentialKaiyun Xin0Ruize Sun1Wanyang Xiao2Weijie Lu3Chenhui Sun4Jietao Lou5Yanyan Xu6Tianbao Chen7Di Wu8Yitian Gao9Zhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, ChinaNatural Drug Discovery Group, School of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UKZhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, ChinaZhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, ChinaZhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaNatural Drug Discovery Group, School of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UKSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaZhejiang Provincial Key Laboratory for Water Environment and Marine, Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, ChinaScorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases. This review provides a comprehensive analysis of scorpion venom peptides, focusing on their roles as voltage-gated sodium (Nav), potassium (Kv), and calcium (Cav) channel modulators. It analyzed Nav1.7 inhibition for analgesia, Kv1.3 blockade for anticancer activity, and membrane disruption for antimicrobial effects. While the low targeting specificity and high toxicity of some scorpion venom peptides pose challenges to their clinical application, recent research has made strides in overcoming these limitations. This review summarizes the latest progress in scorpion venom peptide research, discussing their mechanisms of action, therapeutic potential, and challenges in clinical translation. This work aims to provide new insights and directions for the development of novel therapeutic drugs.https://www.mdpi.com/2072-6651/17/3/114scorpion venom peptidesion channel blockermembrane-targeting mechanismstherapeutic potentialpeptide engineering |
| spellingShingle | Kaiyun Xin Ruize Sun Wanyang Xiao Weijie Lu Chenhui Sun Jietao Lou Yanyan Xu Tianbao Chen Di Wu Yitian Gao Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential Toxins scorpion venom peptides ion channel blocker membrane-targeting mechanisms therapeutic potential peptide engineering |
| title | Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential |
| title_full | Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential |
| title_fullStr | Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential |
| title_full_unstemmed | Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential |
| title_short | Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential |
| title_sort | short peptides from asian scorpions bioactive molecules with promising therapeutic potential |
| topic | scorpion venom peptides ion channel blocker membrane-targeting mechanisms therapeutic potential peptide engineering |
| url | https://www.mdpi.com/2072-6651/17/3/114 |
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