Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood Cells
Objective: to study the effect of different concentrations of oxygen on structural and functional parameters of red blood cells during balanced multicomponent sevoflurane-based endotracheal anesthesia. Subjects and methods. The prospective, randomized trial enrolled 20 persons (aged 52.7±16.2 years)...
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2012-12-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/171 |
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| author | A. V. Marochkov A. L. Lipnitsky S. A. Tochilo N. V. Akulich |
| author_facet | A. V. Marochkov A. L. Lipnitsky S. A. Tochilo N. V. Akulich |
| author_sort | A. V. Marochkov |
| collection | DOAJ |
| description | Objective: to study the effect of different concentrations of oxygen on structural and functional parameters of red blood cells during balanced multicomponent sevoflurane-based endotracheal anesthesia. Subjects and methods. The prospective, randomized trial enrolled 20 persons (aged 52.7±16.2 years) who underwent the same surgical procedure. The patients were divided into 2 groups, which differed inintraoperatively used oxygen concentration in the inspired mixture,50% FiO2 (group 1) and 21% FiO2 (Group 2). A morphological difractometric analysis of patients’ red blood cells was performed preoperatively, intraoperatively, and after anesthesia. Results. In Group 1, red blood cells demonstrated statistically significant trend towards macrocytosis (82.4±23.3 fl before general anesthesia versus 85.1±20.6 fl after anesthesia; р=0.02); in group 2, there were no statistically significant changes in red blood cell volumes. Lateral light scattering was ignificantly decreased after anesthesia in Group 1 (146.2±17.7 U versus 162.9±23.0 U prior to anesthesia (р<0.005) and 156.4±16.3 U during the surgery (р<0.05)). The coefficient of variation in half-height of lateral light scattering of red blood cells was also significantly increased at the final stage of observation in Group 1 (26.3±3.1 U versus 22.1±5.0 U during surgery, рKey words: red blood cells, homeostasis, general anesthesia, hyperoxia, morphological difractometry. |
| format | Article |
| id | doaj-art-9c14480407f744918d7b7d968e045f67 |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2012-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-9c14480407f744918d7b7d968e045f672025-08-20T02:55:49ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102012-12-018610.15360/1813-9779-2012-6-11171Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood CellsA. V. MarochkovA. L. LipnitskyS. A. TochiloN. V. AkulichObjective: to study the effect of different concentrations of oxygen on structural and functional parameters of red blood cells during balanced multicomponent sevoflurane-based endotracheal anesthesia. Subjects and methods. The prospective, randomized trial enrolled 20 persons (aged 52.7±16.2 years) who underwent the same surgical procedure. The patients were divided into 2 groups, which differed inintraoperatively used oxygen concentration in the inspired mixture,50% FiO2 (group 1) and 21% FiO2 (Group 2). A morphological difractometric analysis of patients’ red blood cells was performed preoperatively, intraoperatively, and after anesthesia. Results. In Group 1, red blood cells demonstrated statistically significant trend towards macrocytosis (82.4±23.3 fl before general anesthesia versus 85.1±20.6 fl after anesthesia; р=0.02); in group 2, there were no statistically significant changes in red blood cell volumes. Lateral light scattering was ignificantly decreased after anesthesia in Group 1 (146.2±17.7 U versus 162.9±23.0 U prior to anesthesia (р<0.005) and 156.4±16.3 U during the surgery (р<0.05)). The coefficient of variation in half-height of lateral light scattering of red blood cells was also significantly increased at the final stage of observation in Group 1 (26.3±3.1 U versus 22.1±5.0 U during surgery, рKey words: red blood cells, homeostasis, general anesthesia, hyperoxia, morphological difractometry.https://www.reanimatology.com/rmt/article/view/171эритроцитыгомеостазобщая анестезиягипероксияморфодифрактометрия |
| spellingShingle | A. V. Marochkov A. L. Lipnitsky S. A. Tochilo N. V. Akulich Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood Cells Общая реаниматология эритроциты гомеостаз общая анестезия гипероксия морфодифрактометрия |
| title | Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood Cells |
| title_full | Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood Cells |
| title_fullStr | Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood Cells |
| title_full_unstemmed | Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood Cells |
| title_short | Effect of Different Oxygen Concentrations Used During Multicomponent Endotracheal Anesthesia on the Structural and Functional Parameters of Red Blood Cells |
| title_sort | effect of different oxygen concentrations used during multicomponent endotracheal anesthesia on the structural and functional parameters of red blood cells |
| topic | эритроциты гомеостаз общая анестезия гипероксия морфодифрактометрия |
| url | https://www.reanimatology.com/rmt/article/view/171 |
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