Inhibiting UPF1 methylation enhances tumor immunotherapy sensitivity by reducing nonsense-mediated mRNA decay

Inhibiting UPF1 methylation enhances tumor immunotherapy sensitivity by reducing nonsense-mediated mRNA decay

Summary: Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism. Inhibition of NMD leads to increased expression of tumor neoantigens encoded by genes with premature termination codons (PTCs), thereby enhancing tumor immunogenicity. In this study, we find that protein levels of...

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Bibliographic Details
Main Authors: Shengyu Zhu, Yucong Bai, Dongjing Zhang, Changsheng Huang, Xu Qian, Pengcheng Li, Tianci Xie, Qi Wu, Anyi Liu, Tong Zhu, Wangshuo Yang, Xiaowei She, Mao Li, Zejun Rao, Siqi Chen, Lang Liu, Chengxin Yu, Xiang Liu, Guihua Wang, Guangyong Zhang, Junbo Hu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725006904
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