EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Aim. To assess the effect of pre-hospital administration of statins on the levels of inflammatory markers and matrix metalloproteinases in the se-rum of patients with acute ST-segment elevation myocardial infarction (STEMI).Materials and Methods. We consecutively recruited 175 patients with STEMI (1...
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Kemerovo State Medical University
2019-03-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/130 |
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| author | TAMARA B. Pecherina OLGA V. Gruzdeva OLGA L. Barbarash |
| author_facet | TAMARA B. Pecherina OLGA V. Gruzdeva OLGA L. Barbarash |
| author_sort | TAMARA B. Pecherina |
| collection | DOAJ |
| description | Aim. To assess the effect of pre-hospital administration of statins on the levels of inflammatory markers and matrix metalloproteinases in the se-rum of patients with acute ST-segment elevation myocardial infarction (STEMI).Materials and Methods. We consecutively recruited 175 patients with STEMI (116 (66.3%) men and 59 (33.7%) women, average age 61.3 ± 8.4 years). Serum concentrations of interleukins (IL-6, IL-10, IL-12), C-reactive protein (CRP), tu-mor necrosis factor-α (TNF-α), and matrix metal-loproteinases (MMP-1, -3, -9) as well as blood lipid parameters were evaluated in all patients at the admission and on 12th day after STEMI onset. All the patients were divided into 2 groups depending on pre-hospital use of statins: 136 (77.71%) patients without and 39 (22.29%) patients with statin administration.Results. As compared to the patients without prior statin treatment, those who used statins ≥ 7 days prior to the development of STEMI had significantly lower values of serum low-density lipoproteins [2.91 (1.31; 5.13) vs 1.34 (0.76; 9.77), respectively], IL-6, CRP, TNF-α, and MMP-9 at both time points. In keeping with these ndings, serum level of anti-inflammatory marker IL-10 was two-fold higher in patients taking statins at the pre-hos-pital stage in comparison with those without statin administration. Conclusions. The lack of pre-hospital statin administration in patients with STEMI is associated with the higher values of pro-inflammatory markers (IL-6, CRP, TNF-α), and MMP-9 during in-hospital period. |
| format | Article |
| id | doaj-art-9c0ca0a4f32941a1b62a358f88fbb5f6 |
| institution | DOAJ |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-9c0ca0a4f32941a1b62a358f88fbb5f62025-08-20T03:19:11ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412019-03-01414755129EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTIONTAMARA B. Pecherina0OLGA V. Gruzdeva1OLGA L. Barbarash2Research Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityAim. To assess the effect of pre-hospital administration of statins on the levels of inflammatory markers and matrix metalloproteinases in the se-rum of patients with acute ST-segment elevation myocardial infarction (STEMI).Materials and Methods. We consecutively recruited 175 patients with STEMI (116 (66.3%) men and 59 (33.7%) women, average age 61.3 ± 8.4 years). Serum concentrations of interleukins (IL-6, IL-10, IL-12), C-reactive protein (CRP), tu-mor necrosis factor-α (TNF-α), and matrix metal-loproteinases (MMP-1, -3, -9) as well as blood lipid parameters were evaluated in all patients at the admission and on 12th day after STEMI onset. All the patients were divided into 2 groups depending on pre-hospital use of statins: 136 (77.71%) patients without and 39 (22.29%) patients with statin administration.Results. As compared to the patients without prior statin treatment, those who used statins ≥ 7 days prior to the development of STEMI had significantly lower values of serum low-density lipoproteins [2.91 (1.31; 5.13) vs 1.34 (0.76; 9.77), respectively], IL-6, CRP, TNF-α, and MMP-9 at both time points. In keeping with these ndings, serum level of anti-inflammatory marker IL-10 was two-fold higher in patients taking statins at the pre-hos-pital stage in comparison with those without statin administration. Conclusions. The lack of pre-hospital statin administration in patients with STEMI is associated with the higher values of pro-inflammatory markers (IL-6, CRP, TNF-α), and MMP-9 during in-hospital period.https://fcm.kemsmu.ru/jour/article/view/130инфаркт миокардастатиныматриксные металлопротеиназымаркеры воспаленияmyocardial infarctionstatinsmatrix metalloproteinasesinflammatory markers |
| spellingShingle | TAMARA B. Pecherina OLGA V. Gruzdeva OLGA L. Barbarash EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION Фундаментальная и клиническая медицина инфаркт миокарда статины матриксные металлопротеиназы маркеры воспаления myocardial infarction statins matrix metalloproteinases inflammatory markers |
| title | EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_full | EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_fullStr | EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_full_unstemmed | EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_short | EFFECT OF STATINS ON SERUM CONCENTRATION OF INFLAMMATORY MARKERS AND MATRIX METALLOPROTEINASES IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION |
| title_sort | effect of statins on serum concentration of inflammatory markers and matrix metalloproteinases in patients with acute st segment elevation myocardial infarction |
| topic | инфаркт миокарда статины матриксные металлопротеиназы маркеры воспаления myocardial infarction statins matrix metalloproteinases inflammatory markers |
| url | https://fcm.kemsmu.ru/jour/article/view/130 |
| work_keys_str_mv | AT tamarabpecherina effectofstatinsonserumconcentrationofinflammatorymarkersandmatrixmetalloproteinasesinpatientswithacutestsegmentelevationmyocardialinfarction AT olgavgruzdeva effectofstatinsonserumconcentrationofinflammatorymarkersandmatrixmetalloproteinasesinpatientswithacutestsegmentelevationmyocardialinfarction AT olgalbarbarash effectofstatinsonserumconcentrationofinflammatorymarkersandmatrixmetalloproteinasesinpatientswithacutestsegmentelevationmyocardialinfarction |