Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer

Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer

Abstract Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, with KRAS mutations playing a significant role in its tumorigenesis. Among the KRAS variants, the G13D mutation is associated with poor prognosis and distinctive biological behaviors. This study focuses on the role of H...

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Bibliographic Details
Main Authors: Soo-Yeon Hwang, Yoojeong Seo, Seojeong Park, Seul-Ah Kim, Inhye Moon, Yi Liu, Seojeong Kim, Eun Seon Pak, Sehyun Jung, Hyeyoon Kim, Kyung-Hwa Jeon, Seung Hee Seo, Inyoung Sung, Heetak Lee, So-Yeon Park, Younghwa Na, Tae Il Kim, Youngjoo Kwon
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
KRAS mutation
KRAS G13D
HER2
ELF3
HER2-ELF3-KRAS axis
Online Access:https://doi.org/10.1186/s12943-025-02343-5
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