Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study
Objectives Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in...
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BMJ Publishing Group
2023-04-01
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| Series: | BMJ Open |
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| author | Yi Li Xing Liu Wanhong Yin Yiwei Qin Tongjuan Zou |
| author_facet | Yi Li Xing Liu Wanhong Yin Yiwei Qin Tongjuan Zou |
| author_sort | Yi Li |
| collection | DOAJ |
| description | Objectives Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in sepsis therapy.Design A retrospective cohort study.Setting We screened the Medical Information Mart for Intensive Care (MIMIC-IV), a public database comprising data from critical care subjects at the Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts, USA.Participants A total of 7981 patients, who were admitted to the BIDMC between 2008 and 2019, were analysed based on Sepsis-3 criteria from MIMIC-IV.Primary and secondary outcome measures Primary and secondary outcomes included 30-day mortality after admission and length of intensive care unit (ICU) stay and hospitalisation, respectively.Results Patients with ≤10% reduction in proportion of platelet counts were associated with significantly lower 30-day mortality (14.1% vs 23.5%, p<0.001, Kaplan-Meier analysis, p<0.0001). Multivariable analysis revealed that decreased platelet-count percentage ≤10% on day 4 after ICU admission was associated with lower probability of 30-day non-survival (OR=0.73, 95% CI 0.64 to 0.82, p＜0.001). Patients in the ≤10% group had significantly shorter ICU stays than those in the >10% group (6.8 vs 7.5, p＜0.001). Restricted cubic spline curves revealed that mortality rates decreased with increase in proportion of platelet counts.Conclusions A ≤10% decrease in platelet-count percentage among sepsis patients after treatments is independently associated with decreased 30-day mortality, suggesting that changes in proportion of platelet counts after treatments could be an indicator for assessing the therapeutic effects of sepsis. |
| format | Article |
| id | doaj-art-9bface9c8ef24e5cb33dccf9bf57f41e |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-9bface9c8ef24e5cb33dccf9bf57f41e2024-11-15T22:20:13ZengBMJ Publishing GroupBMJ Open2044-60552023-04-0113410.1136/bmjopen-2022-069027Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational studyYi Li0Xing Liu1Wanhong Yin2Yiwei Qin3Tongjuan Zou4Department of Infectious Diseases, Suining Central Hospital, Suining, ChinaDepartment of Neurosurgery, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Intensive Medicine, Chengdu Medical College, The First Affiliated Hospital, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaObjectives Although platelets have been linked to inflammatory development in sepsis, knowledge on their role as an indicator in sepsis treatment is scarce. Here, we investigated the association between time-dependent changes in platelet counts with mortality rates to reveal the role of platelets in sepsis therapy.Design A retrospective cohort study.Setting We screened the Medical Information Mart for Intensive Care (MIMIC-IV), a public database comprising data from critical care subjects at the Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts, USA.Participants A total of 7981 patients, who were admitted to the BIDMC between 2008 and 2019, were analysed based on Sepsis-3 criteria from MIMIC-IV.Primary and secondary outcome measures Primary and secondary outcomes included 30-day mortality after admission and length of intensive care unit (ICU) stay and hospitalisation, respectively.Results Patients with ≤10% reduction in proportion of platelet counts were associated with significantly lower 30-day mortality (14.1% vs 23.5%, p<0.001, Kaplan-Meier analysis, p<0.0001). Multivariable analysis revealed that decreased platelet-count percentage ≤10% on day 4 after ICU admission was associated with lower probability of 30-day non-survival (OR=0.73, 95% CI 0.64 to 0.82, p＜0.001). Patients in the ≤10% group had significantly shorter ICU stays than those in the >10% group (6.8 vs 7.5, p＜0.001). Restricted cubic spline curves revealed that mortality rates decreased with increase in proportion of platelet counts.Conclusions A ≤10% decrease in platelet-count percentage among sepsis patients after treatments is independently associated with decreased 30-day mortality, suggesting that changes in proportion of platelet counts after treatments could be an indicator for assessing the therapeutic effects of sepsis.https://bmjopen.bmj.com/content/13/4/e069027.full |
| spellingShingle | Yi Li Xing Liu Wanhong Yin Yiwei Qin Tongjuan Zou Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study BMJ Open |
| title | Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study |
| title_full | Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study |
| title_fullStr | Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study |
| title_full_unstemmed | Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study |
| title_short | Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective observational study |
| title_sort | association between minimal decrease in platelet counts and outcomes in septic patients a retrospective observational study |
| url | https://bmjopen.bmj.com/content/13/4/e069027.full |
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