Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development)
Background: Disorders of sex development (DSD) include a diverse array of congenital disorders characterized by the abnormal growth of anatomical sex, chromosomes, gonads, & the brain, all of which are essential to the process of sexual differentiation. Objectives: To evaluate the cosmetic outc...
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South Valley University, Faculty of Medicine
2024-07-01
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| Series: | SVU - International Journal of Medical Sciences |
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| Online Access: | https://svuijm.journals.ekb.eg/article_383889.html |
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| author | ِِAsmaa Gaber Rizk Hamdy Muhammad Hussein Sara Mohammed Habib Abdel-Hamied Nezar Abdelraouf Abo Halawa |
| author_facet | ِِAsmaa Gaber Rizk Hamdy Muhammad Hussein Sara Mohammed Habib Abdel-Hamied Nezar Abdelraouf Abo Halawa |
| author_sort | ِِAsmaa Gaber Rizk |
| collection | DOAJ |
| description | Background: Disorders of sex development (DSD) include a diverse array of congenital disorders characterized by the abnormal growth of anatomical sex, chromosomes, gonads, & the brain, all of which are essential to the process of sexual differentiation.
Objectives: To evaluate the cosmetic outcome of feminizing genitoplasty in DSD.
Patients and methods: This interventional, non-controlled study was conducted on 50 virilizing females at Qena University Hospitals over one year. The study included detailed history, genital examination, Prader staging, serum electrolytes, karyotyping, hormonal profiles, abdominal ultrasound, genitography, cystoscopy, and surgeries (clitroplasty, vaginoplasty, labioplasty). Postoperative care involved antibiotics, analgesics, oral feeding, and vaginal calibration. Outcomes were assessed using Creighton and Lean scores.
Results: 38%of patients were under one year old; 92%had congenital adrenal hyperplasia, and 100% had 21-hydroxylase deficiency. Cosmetic outcomes were favorable, with 82% achieving good results. Postoperative complications were low: stress incontinence(8%), dysuria(6%), difficult micturition(4%), and wound infections(4%). Older age was significantly associated with poorer cosmetic outcomes(p=0.006) and increased stress incontinence(p=0.041), but not with dysuria, difficult micturition, or wound infections(p>0.05).
Conclusion: The number of patients with a decreased aldosterone level in the research cases was 41 (82%). The number of patients with an increased renin level in the research population was 41 (82%). The number of patients with a decreased cortisol level in the research population was 49 (98%). The number of patients with 17-OH-progesterone >20,000 ng/dl in the research population was 41 (82%). The number of patients with increased testosterone levels in the research cases was 50 (100%). |
| format | Article |
| id | doaj-art-9bf9cd3afda34a8e8a9c0b52e876685c |
| institution | Kabale University |
| issn | 2735-427X 2636-3402 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj-art-9bf9cd3afda34a8e8a9c0b52e876685c2025-02-06T10:52:38ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022024-07-0172 603616https://doi.org/10.21608/svuijm.2024.306501.1938Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development)ِِAsmaa Gaber Rizk0 Hamdy Muhammad Hussein 1Sara Mohammed Habib Abdel-Hamied 2Nezar Abdelraouf Abo Halawa 3General Surgery Department, Faculty of Medicine, South Valley University, Qena, EgyptGeneral Surgery Department, Faculty of Medicine, South Valley University, Qena, EgyptGeneral Surgery Department, Faculty of Medicine, South Valley University, Qena, EgyptPediatric Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.Background: Disorders of sex development (DSD) include a diverse array of congenital disorders characterized by the abnormal growth of anatomical sex, chromosomes, gonads, & the brain, all of which are essential to the process of sexual differentiation. Objectives: To evaluate the cosmetic outcome of feminizing genitoplasty in DSD. Patients and methods: This interventional, non-controlled study was conducted on 50 virilizing females at Qena University Hospitals over one year. The study included detailed history, genital examination, Prader staging, serum electrolytes, karyotyping, hormonal profiles, abdominal ultrasound, genitography, cystoscopy, and surgeries (clitroplasty, vaginoplasty, labioplasty). Postoperative care involved antibiotics, analgesics, oral feeding, and vaginal calibration. Outcomes were assessed using Creighton and Lean scores. Results: 38%of patients were under one year old; 92%had congenital adrenal hyperplasia, and 100% had 21-hydroxylase deficiency. Cosmetic outcomes were favorable, with 82% achieving good results. Postoperative complications were low: stress incontinence(8%), dysuria(6%), difficult micturition(4%), and wound infections(4%). Older age was significantly associated with poorer cosmetic outcomes(p=0.006) and increased stress incontinence(p=0.041), but not with dysuria, difficult micturition, or wound infections(p>0.05). Conclusion: The number of patients with a decreased aldosterone level in the research cases was 41 (82%). The number of patients with an increased renin level in the research population was 41 (82%). The number of patients with a decreased cortisol level in the research population was 49 (98%). The number of patients with 17-OH-progesterone >20,000 ng/dl in the research population was 41 (82%). The number of patients with increased testosterone levels in the research cases was 50 (100%).https://svuijm.journals.ekb.eg/article_383889.htmlcosmetic outcome feminizing genitoplasty dsd |
| spellingShingle | ِِAsmaa Gaber Rizk Hamdy Muhammad Hussein Sara Mohammed Habib Abdel-Hamied Nezar Abdelraouf Abo Halawa Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development) SVU - International Journal of Medical Sciences cosmetic outcome feminizing genitoplasty dsd |
| title | Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development) |
| title_full | Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development) |
| title_fullStr | Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development) |
| title_full_unstemmed | Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development) |
| title_short | Cosmetic Outcome of Feminizing Genitoplasty in DSD (Disorders of Sex Development) |
| title_sort | cosmetic outcome of feminizing genitoplasty in dsd disorders of sex development |
| topic | cosmetic outcome feminizing genitoplasty dsd |
| url | https://svuijm.journals.ekb.eg/article_383889.html |
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