Predictors of length of hospital stay in patients with acute COVID-19
The aim of the study was to identify the predictors of length of hospital stay in patients with acute COVID-19, based on the pathophysiological particularities of SARS. Materials and methods: The study was conducted from December 2020 to May 2021 on 103 randomized patients (59 men, mean age 62±13 y...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2023-04-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1474 |
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| author | E. S. Pan’ko S. V. Zhavoronok A. M. Solovchuk S. S. Pan’ko S. V. Pan’ko |
| author_facet | E. S. Pan’ko S. V. Zhavoronok A. M. Solovchuk S. S. Pan’ko S. V. Pan’ko |
| author_sort | E. S. Pan’ko |
| collection | DOAJ |
| description | The aim of the study was to identify the predictors of length of hospital stay in patients with acute COVID-19, based on the pathophysiological particularities of SARS. Materials and methods: The study was conducted from December 2020 to May 2021 on 103 randomized patients (59 men, mean age 62±13 years, body mass index 30.3±5.5 kg/m2 ) with moderate to severe acute COVID-19 infection who were hospitalized for emergency non-invasive oxygen therapy. Log-regression models were used to assess the suitability of some functional spirometric variables and/or SpO2/FiO2 surrogate oxygenation index to predict the duration of inpatient treatment from the day of the examination (≤ 7 vs. > 7 days). Results: The analysis of the receiver operating characteristic curves showed that the relative indicator of the “ventilatory reserve” (the ratio of maximum voluntary ventilation to minute ventilation at rest, VR= MVV / MV) has sufficient sensitivity (82%), specificity (69%) and the area under the curve (AUC=0.7), although the SpO2/FiO2 ratio has a better predictive capacity (78%, 84% and 0.8 accordingly). The model combining these two integral indicators of gas exchange and the respiratory muscles reserve showed the best sensitivity (89%), specificity (84%) and area under the curve (0.9). Conclusion: The proposed model for determining of the hypoxia vector by assessing the severity of ventilation-perfusion dissociation with indicators of oxygenation and ventilation showed that the MVV/MV ratio and SpO2/FiO2 ratio can be used alone and especially in combination, as effective outcome predictors of the acute phase of the infectious process caused by SARS-CoV-2. |
| format | Article |
| id | doaj-art-9bf49294d34f4555ad8307b7e908cda2 |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2023-04-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-9bf49294d34f4555ad8307b7e908cda22025-08-20T03:02:20ZrusJournal InfectologyЖурнал инфектологии2072-67322023-04-01151869210.22625/2072-6732-2023-15-1-86-921057Predictors of length of hospital stay in patients with acute COVID-19E. S. Pan’ko0S. V. Zhavoronok1A. M. Solovchuk2S. S. Pan’ko3S. V. Pan’ko4Brest Regional Clinical HospitalBelarusian State Medical UniversityBrest State Technical UniversityBrest Regional Clinical HospitalBrest Regional Clinical Hospital; Brest State University named after A.S. PushkinThe aim of the study was to identify the predictors of length of hospital stay in patients with acute COVID-19, based on the pathophysiological particularities of SARS. Materials and methods: The study was conducted from December 2020 to May 2021 on 103 randomized patients (59 men, mean age 62±13 years, body mass index 30.3±5.5 kg/m2 ) with moderate to severe acute COVID-19 infection who were hospitalized for emergency non-invasive oxygen therapy. Log-regression models were used to assess the suitability of some functional spirometric variables and/or SpO2/FiO2 surrogate oxygenation index to predict the duration of inpatient treatment from the day of the examination (≤ 7 vs. > 7 days). Results: The analysis of the receiver operating characteristic curves showed that the relative indicator of the “ventilatory reserve” (the ratio of maximum voluntary ventilation to minute ventilation at rest, VR= MVV / MV) has sufficient sensitivity (82%), specificity (69%) and the area under the curve (AUC=0.7), although the SpO2/FiO2 ratio has a better predictive capacity (78%, 84% and 0.8 accordingly). The model combining these two integral indicators of gas exchange and the respiratory muscles reserve showed the best sensitivity (89%), specificity (84%) and area under the curve (0.9). Conclusion: The proposed model for determining of the hypoxia vector by assessing the severity of ventilation-perfusion dissociation with indicators of oxygenation and ventilation showed that the MVV/MV ratio and SpO2/FiO2 ratio can be used alone and especially in combination, as effective outcome predictors of the acute phase of the infectious process caused by SARS-CoV-2.https://journal.niidi.ru/jofin/article/view/1474covid-19silent hypoxiaspirometrymvv/ mv ratiorespiratory musclepulse oximetrysao2 /fio2 ratiosars-cov-2outcome prediction |
| spellingShingle | E. S. Pan’ko S. V. Zhavoronok A. M. Solovchuk S. S. Pan’ko S. V. Pan’ko Predictors of length of hospital stay in patients with acute COVID-19 Журнал инфектологии covid-19 silent hypoxia spirometry mvv/ mv ratio respiratory muscle pulse oximetry sao2 /fio2 ratio sars-cov-2 outcome prediction |
| title | Predictors of length of hospital stay in patients with acute COVID-19 |
| title_full | Predictors of length of hospital stay in patients with acute COVID-19 |
| title_fullStr | Predictors of length of hospital stay in patients with acute COVID-19 |
| title_full_unstemmed | Predictors of length of hospital stay in patients with acute COVID-19 |
| title_short | Predictors of length of hospital stay in patients with acute COVID-19 |
| title_sort | predictors of length of hospital stay in patients with acute covid 19 |
| topic | covid-19 silent hypoxia spirometry mvv/ mv ratio respiratory muscle pulse oximetry sao2 /fio2 ratio sars-cov-2 outcome prediction |
| url | https://journal.niidi.ru/jofin/article/view/1474 |
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