Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort
Abstract At least 45% of dementia and 60% of stroke cases are due to modifiable risk factors and could in part be prevented through healthy behavior. This cross-sectional study clustered and characterized a U.S. cohort’s knowledge and practice of healthy behavior associated with dementia and stroke....
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-99246-8 |
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| author | Jasper R. Senff Reinier W. P. Tack Benjamin Y. Q. Tan Savvina Prapiadou Tamara N. Kimball Sharon Ng Jonathan Duskin Mark Jun Shah-Ostrowski Courtney Nunley H. Bart Brouwers Zeina Chemali Gregory Fricchione Rudolph E. Tanzi Koen Pouwels Jonathan Rosand Nirupama Yechoor Christopher D. Anderson Sanjula D. Singh |
| author_facet | Jasper R. Senff Reinier W. P. Tack Benjamin Y. Q. Tan Savvina Prapiadou Tamara N. Kimball Sharon Ng Jonathan Duskin Mark Jun Shah-Ostrowski Courtney Nunley H. Bart Brouwers Zeina Chemali Gregory Fricchione Rudolph E. Tanzi Koen Pouwels Jonathan Rosand Nirupama Yechoor Christopher D. Anderson Sanjula D. Singh |
| author_sort | Jasper R. Senff |
| collection | DOAJ |
| description | Abstract At least 45% of dementia and 60% of stroke cases are due to modifiable risk factors and could in part be prevented through healthy behavior. This cross-sectional study clustered and characterized a U.S. cohort’s knowledge and practice of healthy behavior associated with dementia and stroke. A total of 1,478 participants (mean age: 45.5 years, 51.8% female) were included. A hierarchical cluster analysis was performed to identify clusters based on the level of knowledge and practice of healthy behavior. We defined knowledge as recognizing eight modifiable risk factors (alcohol, diet, smoking, physical activity, sleep, stress, social relationships, and purpose in life) as important. We defined practice as complying with validated recommendations for each healthy behavior. Three clusters emerged: (I) high knowledge and poor practice (II) high knowledge and good practice, and (III) lower knowledge and poor practice. Participants in the high knowledge and good practice cluster were statistically significantly older, more educated, perceived fewer barriers (financial and time limitations), and more facilitators (motivation or knowing someone with dementia or stroke) compared to the other clusters. Our findings could assist in tailoring preventative strategies to enhance knowledge, translating knowledge into practice, and addressing particular facilitators and barriers per identified cluster. |
| format | Article |
| id | doaj-art-9bf3c0e3fa114ad9a14c44cbe091e06d |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9bf3c0e3fa114ad9a14c44cbe091e06d2025-08-20T02:10:56ZengNature PortfolioScientific Reports2045-23222025-04-0115111210.1038/s41598-025-99246-8Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohortJasper R. Senff0Reinier W. P. Tack1Benjamin Y. Q. Tan2Savvina Prapiadou3Tamara N. Kimball4Sharon Ng5Jonathan Duskin6Mark Jun Shah-Ostrowski7Courtney Nunley8H. Bart Brouwers9Zeina Chemali10Gregory Fricchione11Rudolph E. Tanzi12Koen Pouwels13Jonathan Rosand14Nirupama Yechoor15Christopher D. Anderson16Sanjula D. Singh17Brain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalNuffield Department of Population Health, University of OxfordBrain Care Labs, Massachusetts General HospitalDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center UtrechtBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalDepartment of Neurology, Massachusetts General HospitalNuffield Department of Population Health, University of OxfordBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalBrain Care Labs, Massachusetts General HospitalAbstract At least 45% of dementia and 60% of stroke cases are due to modifiable risk factors and could in part be prevented through healthy behavior. This cross-sectional study clustered and characterized a U.S. cohort’s knowledge and practice of healthy behavior associated with dementia and stroke. A total of 1,478 participants (mean age: 45.5 years, 51.8% female) were included. A hierarchical cluster analysis was performed to identify clusters based on the level of knowledge and practice of healthy behavior. We defined knowledge as recognizing eight modifiable risk factors (alcohol, diet, smoking, physical activity, sleep, stress, social relationships, and purpose in life) as important. We defined practice as complying with validated recommendations for each healthy behavior. Three clusters emerged: (I) high knowledge and poor practice (II) high knowledge and good practice, and (III) lower knowledge and poor practice. Participants in the high knowledge and good practice cluster were statistically significantly older, more educated, perceived fewer barriers (financial and time limitations), and more facilitators (motivation or knowing someone with dementia or stroke) compared to the other clusters. Our findings could assist in tailoring preventative strategies to enhance knowledge, translating knowledge into practice, and addressing particular facilitators and barriers per identified cluster.https://doi.org/10.1038/s41598-025-99246-8KnowledgePracticeHealthy behaviorsDementiaStrokePrevention |
| spellingShingle | Jasper R. Senff Reinier W. P. Tack Benjamin Y. Q. Tan Savvina Prapiadou Tamara N. Kimball Sharon Ng Jonathan Duskin Mark Jun Shah-Ostrowski Courtney Nunley H. Bart Brouwers Zeina Chemali Gregory Fricchione Rudolph E. Tanzi Koen Pouwels Jonathan Rosand Nirupama Yechoor Christopher D. Anderson Sanjula D. Singh Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort Scientific Reports Knowledge Practice Healthy behaviors Dementia Stroke Prevention |
| title | Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort |
| title_full | Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort |
| title_fullStr | Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort |
| title_full_unstemmed | Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort |
| title_short | Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort |
| title_sort | knowledge and practice of healthy behaviors for dementia and stroke prevention in a united states cohort |
| topic | Knowledge Practice Healthy behaviors Dementia Stroke Prevention |
| url | https://doi.org/10.1038/s41598-025-99246-8 |
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