Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity
Abstract Adriamycin (ADR), as an anti-cancer drug in routine clinical application, is utilized to treat various cancers such as ovarian cancer, hematological malignant tumor, and endometrial carcinoma. However, its serious dose-dependent cardiotoxicity extremely limits its clinical application. Curr...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-03-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02389-w |
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| _version_ | 1850057587447300096 |
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| author | Zheng Wang Yanli Zhu Yu Yao Wenyu Zhang Bo Wang Jing Wang Yang Yang Liwen Liu |
| author_facet | Zheng Wang Yanli Zhu Yu Yao Wenyu Zhang Bo Wang Jing Wang Yang Yang Liwen Liu |
| author_sort | Zheng Wang |
| collection | DOAJ |
| description | Abstract Adriamycin (ADR), as an anti-cancer drug in routine clinical application, is utilized to treat various cancers such as ovarian cancer, hematological malignant tumor, and endometrial carcinoma. However, its serious dose-dependent cardiotoxicity extremely limits its clinical application. Currently, there remains a dearth of therapeutic agents to mitigate ADR-induced cardiotoxicity. Extensive research has demonstrated that ADR can simultaneously trigger various regulated cell death (RCD) pathways, such as apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis. Therefore, drugs targeting these RCD pathways may represent effective strategies for treating ADR-induced cardiotoxicity. Natural products, with their wide availability, low cost, and diverse pharmacological activities, have increasingly gained attention. Various natural products, including polyphenols, flavonoids, terpenoids, and alkaloids, can target the RCD pathways involved in ADR-induced cardiotoxicity. Furthermore, these natural products have exhibited excellent properties in preclinical studies or in vitro experiments. This review summarizes the mechanisms of RCD in ADR-induced cardiotoxicity and systematically reviews the natural products targeting these RCD pathways. Finally, we propose future research directions of natural products in this field. |
| format | Article |
| id | doaj-art-9bf36c5b3201414a959b7c85a9f6906f |
| institution | DOAJ |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-9bf36c5b3201414a959b7c85a9f6906f2025-08-20T02:51:24ZengNature Publishing GroupCell Death Discovery2058-77162025-03-0111111510.1038/s41420-025-02389-wNatural products targeting regulated cell deaths for adriamycin-induced cardiotoxicityZheng Wang0Yanli Zhu1Yu Yao2Wenyu Zhang3Bo Wang4Jing Wang5Yang Yang6Liwen Liu7Xijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, The Fourth Military Medical UniversityXi’an Key Laboratory of Innovative Drug Research for Heart Failure, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest UniversityXi’an Key Laboratory of Innovative Drug Research for Heart Failure, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest UniversityXi’an Key Laboratory of Innovative Drug Research for Heart Failure, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest UniversityXijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, The Fourth Military Medical UniversityXijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, The Fourth Military Medical UniversityXi’an Key Laboratory of Innovative Drug Research for Heart Failure, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest UniversityXijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, The Fourth Military Medical UniversityAbstract Adriamycin (ADR), as an anti-cancer drug in routine clinical application, is utilized to treat various cancers such as ovarian cancer, hematological malignant tumor, and endometrial carcinoma. However, its serious dose-dependent cardiotoxicity extremely limits its clinical application. Currently, there remains a dearth of therapeutic agents to mitigate ADR-induced cardiotoxicity. Extensive research has demonstrated that ADR can simultaneously trigger various regulated cell death (RCD) pathways, such as apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis. Therefore, drugs targeting these RCD pathways may represent effective strategies for treating ADR-induced cardiotoxicity. Natural products, with their wide availability, low cost, and diverse pharmacological activities, have increasingly gained attention. Various natural products, including polyphenols, flavonoids, terpenoids, and alkaloids, can target the RCD pathways involved in ADR-induced cardiotoxicity. Furthermore, these natural products have exhibited excellent properties in preclinical studies or in vitro experiments. This review summarizes the mechanisms of RCD in ADR-induced cardiotoxicity and systematically reviews the natural products targeting these RCD pathways. Finally, we propose future research directions of natural products in this field.https://doi.org/10.1038/s41420-025-02389-w |
| spellingShingle | Zheng Wang Yanli Zhu Yu Yao Wenyu Zhang Bo Wang Jing Wang Yang Yang Liwen Liu Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity Cell Death Discovery |
| title | Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity |
| title_full | Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity |
| title_fullStr | Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity |
| title_full_unstemmed | Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity |
| title_short | Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity |
| title_sort | natural products targeting regulated cell deaths for adriamycin induced cardiotoxicity |
| url | https://doi.org/10.1038/s41420-025-02389-w |
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