Alzheimer's disease mechanisms in peripheral cells: Promises and challenges
Abstract Introduction Development of efficacious therapeutic interventions for Alzheimer's disease (AD) is hampered by the lack of understanding early disease mechanisms, biomarkers, and models that mimic complex pathophysiology of human disease. Methods This article aims to assess to what exte...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.06.008 |
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| _version_ | 1849688369310728192 |
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| author | Eugenia Trushina |
| author_facet | Eugenia Trushina |
| author_sort | Eugenia Trushina |
| collection | DOAJ |
| description | Abstract Introduction Development of efficacious therapeutic interventions for Alzheimer's disease (AD) is hampered by the lack of understanding early disease mechanisms, biomarkers, and models that mimic complex pathophysiology of human disease. Methods This article aims to assess to what extent peripheral cells recapitulate molecular mechanisms altered in the brain and could be used as translational models for the development of individualized medicine for AD. Results Multiple studies suggest that AD is a systemic disorder with an active crosstalk between brain and periphery where multiple pathways altered in the brain cells are also affected in plasma, cerebrospinal fluid, and other peripheral cells of AD patients. Discussion Additional studies to validate molecular mechanisms in peripheral cells using advanced system biology techniques and well‐characterized cohorts of AD patients together with the development of standardized protocols should be considered to support the application of peripheral cells in AD research. |
| format | Article |
| id | doaj-art-9bf2cc4aba1f427c94770ebdaaaf0ee9 |
| institution | DOAJ |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-9bf2cc4aba1f427c94770ebdaaaf0ee92025-08-20T03:22:00ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-015165266010.1016/j.trci.2019.06.008Alzheimer's disease mechanisms in peripheral cells: Promises and challengesEugenia Trushina0Department of NeurologyMayo ClinicRochesterMNUSAAbstract Introduction Development of efficacious therapeutic interventions for Alzheimer's disease (AD) is hampered by the lack of understanding early disease mechanisms, biomarkers, and models that mimic complex pathophysiology of human disease. Methods This article aims to assess to what extent peripheral cells recapitulate molecular mechanisms altered in the brain and could be used as translational models for the development of individualized medicine for AD. Results Multiple studies suggest that AD is a systemic disorder with an active crosstalk between brain and periphery where multiple pathways altered in the brain cells are also affected in plasma, cerebrospinal fluid, and other peripheral cells of AD patients. Discussion Additional studies to validate molecular mechanisms in peripheral cells using advanced system biology techniques and well‐characterized cohorts of AD patients together with the development of standardized protocols should be considered to support the application of peripheral cells in AD research.https://doi.org/10.1016/j.trci.2019.06.008Alzheimer's diseaseBrain‐periphery axisPrimary skin fibroblastsMitochondriaMetabolismBioenergetics |
| spellingShingle | Eugenia Trushina Alzheimer's disease mechanisms in peripheral cells: Promises and challenges Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease Brain‐periphery axis Primary skin fibroblasts Mitochondria Metabolism Bioenergetics |
| title | Alzheimer's disease mechanisms in peripheral cells: Promises and challenges |
| title_full | Alzheimer's disease mechanisms in peripheral cells: Promises and challenges |
| title_fullStr | Alzheimer's disease mechanisms in peripheral cells: Promises and challenges |
| title_full_unstemmed | Alzheimer's disease mechanisms in peripheral cells: Promises and challenges |
| title_short | Alzheimer's disease mechanisms in peripheral cells: Promises and challenges |
| title_sort | alzheimer s disease mechanisms in peripheral cells promises and challenges |
| topic | Alzheimer's disease Brain‐periphery axis Primary skin fibroblasts Mitochondria Metabolism Bioenergetics |
| url | https://doi.org/10.1016/j.trci.2019.06.008 |
| work_keys_str_mv | AT eugeniatrushina alzheimersdiseasemechanismsinperipheralcellspromisesandchallenges |