Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength
BackgroundSemantic intrusion errors (SIEs) are associated with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). It is unknown whether accounting for maximum learning capacity still leads to an increase in SIEs when elevated plasma p-tau217, a biological indicator of underlying A...
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Frontiers Media S.A.
2025-07-01
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| author | Rosie E. Curiel Cid Rosie E. Curiel Cid David Vaillancourt David Vaillancourt Alexandra Ortega Alexandra Ortega Elizabeth A. Crocco Elizabeth A. Crocco Kirsten Crenshaw Kirsten Crenshaw Stephanie M. Remedios Breton M. Asken Breton M. Asken Melissa J. Armstrong Melissa J. Armstrong Idaly Velez Uribe Idaly Velez Uribe Wei-en Wang Wei-en Wang Monica Rosselli Monica Rosselli Malek Adjouadi Malek Adjouadi Michael Marsiske Michael Marsiske Warren W. Barker Warren W. Barker Steven DeKosky Steven DeKosky Glenn Smith Glenn Smith Ranjan Duara Ranjan Duara David A. Loewenstein David A. Loewenstein |
| author_facet | Rosie E. Curiel Cid Rosie E. Curiel Cid David Vaillancourt David Vaillancourt Alexandra Ortega Alexandra Ortega Elizabeth A. Crocco Elizabeth A. Crocco Kirsten Crenshaw Kirsten Crenshaw Stephanie M. Remedios Breton M. Asken Breton M. Asken Melissa J. Armstrong Melissa J. Armstrong Idaly Velez Uribe Idaly Velez Uribe Wei-en Wang Wei-en Wang Monica Rosselli Monica Rosselli Malek Adjouadi Malek Adjouadi Michael Marsiske Michael Marsiske Warren W. Barker Warren W. Barker Steven DeKosky Steven DeKosky Glenn Smith Glenn Smith Ranjan Duara Ranjan Duara David A. Loewenstein David A. Loewenstein |
| author_sort | Rosie E. Curiel Cid |
| collection | DOAJ |
| description | BackgroundSemantic intrusion errors (SIEs) are associated with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). It is unknown whether accounting for maximum learning capacity still leads to an increase in SIEs when elevated plasma p-tau217, a biological indicator of underlying AD, is present.MethodsOne hundred fifty-eight older adult participants completed the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), a sensitive cognitive challenge test designed to elicit SIEs. Of these, 108 were clinically diagnosed with amnestic MCI (aMCI). Fifty-eight individuals met or exceeded a plasma p-tau217 positivity of >0.55 pg/ml, while 50 individuals scored below this threshold.ResultsAfter adjusting for demographic covariates and maximum learning capacity, the aMCI p-tau217+ group evidenced more SIEs compared to aMCI p-tau217- on the first (list B1; p = 0.035) and second trials of the competing list (list B2; p = 0.006). Biological predictors such as ApoE ε4 status, higher p-tau217, and older age were predictors of an elevated number of SIEs [list B2: F (3,104) = 10.92; p = 0.001; R = 0.489)].ConclusionsUnlike previous studies that used amyloid PET or other plasma biomarkers, individuals with aMCI p-tau217+ evidenced more SIEs, even after adjusting for their initial learning capacity, a covariate that has not been studied previously. These findings support that SIEs are more prevalent in the presence of underlying AD pathology and occur independent of learning deficits. |
| format | Article |
| id | doaj-art-9bf181401d5447a2ada371e1db6cb082 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-9bf181401d5447a2ada371e1db6cb0822025-08-20T02:50:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16136941613694Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strengthRosie E. Curiel Cid0Rosie E. Curiel Cid1David Vaillancourt2David Vaillancourt3Alexandra Ortega4Alexandra Ortega5Elizabeth A. Crocco6Elizabeth A. Crocco7Kirsten Crenshaw8Kirsten Crenshaw9Stephanie M. Remedios10Breton M. Asken11Breton M. Asken12Melissa J. Armstrong13Melissa J. Armstrong14Idaly Velez Uribe15Idaly Velez Uribe16Wei-en Wang17Wei-en Wang18Monica Rosselli19Monica Rosselli20Malek Adjouadi21Malek Adjouadi22Michael Marsiske23Michael Marsiske24Warren W. Barker25Warren W. Barker26Steven DeKosky27Steven DeKosky28Glenn Smith29Glenn Smith30Ranjan Duara31Ranjan Duara32David A. Loewenstein33David A. Loewenstein341Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging (CNSA), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Applied Physiology and Kinesiology, Gainesville, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging (CNSA), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging (CNSA), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging (CNSA), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging (CNSA), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Neurology, University of Florida College of Medicine, Gainesville, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Applied Physiology and Kinesiology, Gainesville, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Psychology, Florida Atlantic University, Boca Raton, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesCenter for Advanced Technology and Education, Florida International University, Miami, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, United States1Florida Alzheimer's Disease Research Center (ADRC), Miami, FL, United StatesCenter for Cognitive Neuroscience and Aging (CNSA), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United StatesBackgroundSemantic intrusion errors (SIEs) are associated with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). It is unknown whether accounting for maximum learning capacity still leads to an increase in SIEs when elevated plasma p-tau217, a biological indicator of underlying AD, is present.MethodsOne hundred fifty-eight older adult participants completed the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), a sensitive cognitive challenge test designed to elicit SIEs. Of these, 108 were clinically diagnosed with amnestic MCI (aMCI). Fifty-eight individuals met or exceeded a plasma p-tau217 positivity of >0.55 pg/ml, while 50 individuals scored below this threshold.ResultsAfter adjusting for demographic covariates and maximum learning capacity, the aMCI p-tau217+ group evidenced more SIEs compared to aMCI p-tau217- on the first (list B1; p = 0.035) and second trials of the competing list (list B2; p = 0.006). Biological predictors such as ApoE ε4 status, higher p-tau217, and older age were predictors of an elevated number of SIEs [list B2: F (3,104) = 10.92; p = 0.001; R = 0.489)].ConclusionsUnlike previous studies that used amyloid PET or other plasma biomarkers, individuals with aMCI p-tau217+ evidenced more SIEs, even after adjusting for their initial learning capacity, a covariate that has not been studied previously. These findings support that SIEs are more prevalent in the presence of underlying AD pathology and occur independent of learning deficits.https://www.frontiersin.org/articles/10.3389/fneur.2025.1613694/fullmild cognitive impairmentAlzheimer's diseasesemantic interferencesemantic intrusion errorsLASSI-Lplasma biomarkers |
| spellingShingle | Rosie E. Curiel Cid Rosie E. Curiel Cid David Vaillancourt David Vaillancourt Alexandra Ortega Alexandra Ortega Elizabeth A. Crocco Elizabeth A. Crocco Kirsten Crenshaw Kirsten Crenshaw Stephanie M. Remedios Breton M. Asken Breton M. Asken Melissa J. Armstrong Melissa J. Armstrong Idaly Velez Uribe Idaly Velez Uribe Wei-en Wang Wei-en Wang Monica Rosselli Monica Rosselli Malek Adjouadi Malek Adjouadi Michael Marsiske Michael Marsiske Warren W. Barker Warren W. Barker Steven DeKosky Steven DeKosky Glenn Smith Glenn Smith Ranjan Duara Ranjan Duara David A. Loewenstein David A. Loewenstein Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength Frontiers in Neurology mild cognitive impairment Alzheimer's disease semantic interference semantic intrusion errors LASSI-L plasma biomarkers |
| title | Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength |
| title_full | Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength |
| title_fullStr | Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength |
| title_full_unstemmed | Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength |
| title_short | Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217- after adjusting for initial learning strength |
| title_sort | semantic intrusion errors differentiate between amnestic mci who are plasma p tau217 from p tau217 after adjusting for initial learning strength |
| topic | mild cognitive impairment Alzheimer's disease semantic interference semantic intrusion errors LASSI-L plasma biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1613694/full |
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