The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study
Abstract Background Few studies to date have explored correlations between red blood cell distribution width (RDW) and prognostic outcomes in acute ischemic stroke (AIS) patients, and conclusions based on the available evidence are controversial. This study was designed to better clarify the associa...
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2025-07-01
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| author | Qin Xiong Dong Kang Shu-ming Xiong Dong-ping Wu Xin Luo Wen-pei Zhang Jing Tang Zheng-guang He |
| author_facet | Qin Xiong Dong Kang Shu-ming Xiong Dong-ping Wu Xin Luo Wen-pei Zhang Jing Tang Zheng-guang He |
| author_sort | Qin Xiong |
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| description | Abstract Background Few studies to date have explored correlations between red blood cell distribution width (RDW) and prognostic outcomes in acute ischemic stroke (AIS) patients, and conclusions based on the available evidence are controversial. This study was designed to better clarify the association between RDW and 3-month prognostic outcomes in AIS patients. Methods This was a secondary analysis of a cohort study. The prospective cohort used to conduct these analyses was comprised of 1,901 AIS patients who underwent treatment in South Korea between January 2010 and December 2016. A modified Rankin Scale (mRS) value above 2 was used to define a poor 3-month prognosis. The link between RDW and poor 3-month prognostic outcomes in subjects with AIS was explored with a binary logistic regression model, with further subgroup analyses and interaction tests also being conducted. Results Of 1,901 individuals analyzed in this study, 1,167 (61.4%) were male, and 543 (28.6%) met the criteria for poor 3-month outcomes. Following adjustment for confounding factors, RDW was positively correlated with poor 3-month outcomes in these individuals with AIS (OR = 1.12, 95% CI; 1.03–1.23, P = 0.0120). Subgroup analyses demonstrated a consistent positive association (OR > 1.0) between elevated RDW and adverse outcomes across the majority of baseline characteristics. No interactions were observed between RDW and poor 3-month outcomes among AIS patients. Conclusion These results demonstrate a positive correlation between RDW and poor 3-month prognosis among AIS patients. The findings suggest RDW may serve as a practical prognostic biomarker, warranting further validation in diverse populations. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
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| series | BMC Neurology |
| spelling | doaj-art-9be959ee70e4420bac8b8546b2fd029c2025-08-20T04:02:55ZengBMCBMC Neurology1471-23772025-07-0125111110.1186/s12883-025-04309-yThe link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort studyQin Xiong0Dong Kang1Shu-ming Xiong2Dong-ping Wu3Xin Luo4Wen-pei Zhang5Jing Tang6Zheng-guang He7Department of Intensive Care Unit, The Third People’s Hospital of SuiningDepartment of neurosurgery, The Third People’s Hospital of SuiningDepartment of Intensive Care Unit, The Third People’s Hospital of SuiningDepartment of Intensive Care Unit, The Third People’s Hospital of SuiningDepartment of Intensive Care Unit, The Third People’s Hospital of SuiningDepartment of Intensive Care Unit, The Third People’s Hospital of SuiningDepartment of Intensive Care Unit, The Third People’s Hospital of SuiningDepartment of Respiratory Medicine, The Third People’s Hospital of SuiningAbstract Background Few studies to date have explored correlations between red blood cell distribution width (RDW) and prognostic outcomes in acute ischemic stroke (AIS) patients, and conclusions based on the available evidence are controversial. This study was designed to better clarify the association between RDW and 3-month prognostic outcomes in AIS patients. Methods This was a secondary analysis of a cohort study. The prospective cohort used to conduct these analyses was comprised of 1,901 AIS patients who underwent treatment in South Korea between January 2010 and December 2016. A modified Rankin Scale (mRS) value above 2 was used to define a poor 3-month prognosis. The link between RDW and poor 3-month prognostic outcomes in subjects with AIS was explored with a binary logistic regression model, with further subgroup analyses and interaction tests also being conducted. Results Of 1,901 individuals analyzed in this study, 1,167 (61.4%) were male, and 543 (28.6%) met the criteria for poor 3-month outcomes. Following adjustment for confounding factors, RDW was positively correlated with poor 3-month outcomes in these individuals with AIS (OR = 1.12, 95% CI; 1.03–1.23, P = 0.0120). Subgroup analyses demonstrated a consistent positive association (OR > 1.0) between elevated RDW and adverse outcomes across the majority of baseline characteristics. No interactions were observed between RDW and poor 3-month outcomes among AIS patients. Conclusion These results demonstrate a positive correlation between RDW and poor 3-month prognosis among AIS patients. The findings suggest RDW may serve as a practical prognostic biomarker, warranting further validation in diverse populations.https://doi.org/10.1186/s12883-025-04309-yIschemic strokeRed blood cell distribution widthPoor prognosisModified Rankin scale |
| spellingShingle | Qin Xiong Dong Kang Shu-ming Xiong Dong-ping Wu Xin Luo Wen-pei Zhang Jing Tang Zheng-guang He The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study BMC Neurology Ischemic stroke Red blood cell distribution width Poor prognosis Modified Rankin scale |
| title | The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study |
| title_full | The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study |
| title_fullStr | The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study |
| title_full_unstemmed | The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study |
| title_short | The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study |
| title_sort | link between red blood cell distribution width and 3 month prognosis in acute ischemic stroke patients a secondary analysis of a cohort study |
| topic | Ischemic stroke Red blood cell distribution width Poor prognosis Modified Rankin scale |
| url | https://doi.org/10.1186/s12883-025-04309-y |
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