Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study

Background/Objectives: The management of oropharyngeal squamous cell carcinoma (OPSCC) often involves multidisciplinary decision-making to optimize patient outcomes. Surgery and chemoradiation therapy (CRT) represent the two main treatment modalities. The aim of this cross-sectional study was to pro...

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Main Authors: Giuseppe Riva, Dario Gamba, Simone Moglio, Giuseppe Carlo Iorio, Chiara Cavallin, Umberto Ricardi, Mario Airoldi, Andrea Canale, Andrea Albera, Giancarlo Pecorari
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Diseases
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Online Access:https://www.mdpi.com/2079-9721/13/4/106
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author Giuseppe Riva
Dario Gamba
Simone Moglio
Giuseppe Carlo Iorio
Chiara Cavallin
Umberto Ricardi
Mario Airoldi
Andrea Canale
Andrea Albera
Giancarlo Pecorari
author_facet Giuseppe Riva
Dario Gamba
Simone Moglio
Giuseppe Carlo Iorio
Chiara Cavallin
Umberto Ricardi
Mario Airoldi
Andrea Canale
Andrea Albera
Giancarlo Pecorari
author_sort Giuseppe Riva
collection DOAJ
description Background/Objectives: The management of oropharyngeal squamous cell carcinoma (OPSCC) often involves multidisciplinary decision-making to optimize patient outcomes. Surgery and chemoradiation therapy (CRT) represent the two main treatment modalities. The aim of this cross-sectional study was to provide a comprehensive analysis of quality of life, speech, swallowing, sleep, psychological distress, and nutritional status in OPSCC patients treated with either surgery or CRT. Methods: Thirty subjects were divided into two groups based on treatment modality (>12-month follow-up): (A) surgery ± adjuvant treatment (15 patients); (B) exclusive CRT (15 patients). A multidimensional evaluation was performed by means of validated questionnaires. The following parameters were analyzed: quality of life, speech, swallowing, sleep quality, risk of sleep apnea, sleepiness, psychological distress, pain, and nutritional status. Results: No statistically significant difference was found between the two study groups for every parameter. The EORTC QLQ-C30 globally showed a good quality of life in both groups. Poor sleep quality was observed in 9 (60%) subjects in group A and in 6 (40%) patients in group B, respectively. Low, intermediate and high risk of malnutrition was observed in 73.3%, 20.0% and 6.7% of cases in group A, and in 93.3%, 6.7% and 0.0% in group B, respectively. Conclusions: Surgery and exclusive chemoradiotherapy appear to yield similar long-term outcomes across all evaluated dimensions, including quality of life, speech, swallowing, sleep, psychological distress, and nutritional status.
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spelling doaj-art-9be78b86f37245c9ba6eb4fa90fcca7c2025-08-20T02:28:28ZengMDPI AGDiseases2079-97212025-04-0113410610.3390/diseases13040106Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional StudyGiuseppe Riva0Dario Gamba1Simone Moglio2Giuseppe Carlo Iorio3Chiara Cavallin4Umberto Ricardi5Mario Airoldi6Andrea Canale7Andrea Albera8Giancarlo Pecorari9Division of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Radiation Oncology, Department of Oncology, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Radiation Oncology, Department of Oncology, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Radiation Oncology, Department of Oncology, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Medical Oncology, Department of Oncology, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, ItalyDivision of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, ItalyBackground/Objectives: The management of oropharyngeal squamous cell carcinoma (OPSCC) often involves multidisciplinary decision-making to optimize patient outcomes. Surgery and chemoradiation therapy (CRT) represent the two main treatment modalities. The aim of this cross-sectional study was to provide a comprehensive analysis of quality of life, speech, swallowing, sleep, psychological distress, and nutritional status in OPSCC patients treated with either surgery or CRT. Methods: Thirty subjects were divided into two groups based on treatment modality (>12-month follow-up): (A) surgery ± adjuvant treatment (15 patients); (B) exclusive CRT (15 patients). A multidimensional evaluation was performed by means of validated questionnaires. The following parameters were analyzed: quality of life, speech, swallowing, sleep quality, risk of sleep apnea, sleepiness, psychological distress, pain, and nutritional status. Results: No statistically significant difference was found between the two study groups for every parameter. The EORTC QLQ-C30 globally showed a good quality of life in both groups. Poor sleep quality was observed in 9 (60%) subjects in group A and in 6 (40%) patients in group B, respectively. Low, intermediate and high risk of malnutrition was observed in 73.3%, 20.0% and 6.7% of cases in group A, and in 93.3%, 6.7% and 0.0% in group B, respectively. Conclusions: Surgery and exclusive chemoradiotherapy appear to yield similar long-term outcomes across all evaluated dimensions, including quality of life, speech, swallowing, sleep, psychological distress, and nutritional status.https://www.mdpi.com/2079-9721/13/4/106oropharyngeal canceroropharyngeal squamous cell carcinomachemoradiationsurgeryquality of lifesleep
spellingShingle Giuseppe Riva
Dario Gamba
Simone Moglio
Giuseppe Carlo Iorio
Chiara Cavallin
Umberto Ricardi
Mario Airoldi
Andrea Canale
Andrea Albera
Giancarlo Pecorari
Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study
Diseases
oropharyngeal cancer
oropharyngeal squamous cell carcinoma
chemoradiation
surgery
quality of life
sleep
title Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study
title_full Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study
title_fullStr Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study
title_full_unstemmed Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study
title_short Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study
title_sort surgery versus chemoradiation therapy for oropharyngeal squamous cell carcinoma a multidimensional cross sectional study
topic oropharyngeal cancer
oropharyngeal squamous cell carcinoma
chemoradiation
surgery
quality of life
sleep
url https://www.mdpi.com/2079-9721/13/4/106
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