Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis
Background. To evaluate the potential diagnostic value of CDI of retrobulbar hemodynamic changes in NTG patients. Methods. Relevant publications which included PSV, EDV, and RI of OA, CRA, NPCA, and TPCA in NTG patients and normal controls measured by CDI were retrieved from the Cochrane Central Reg...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/919610 |
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| author | Shuo Xu Shouyue Huang Zhongjing Lin Wangmin Liu Yisheng Zhong |
| author_facet | Shuo Xu Shouyue Huang Zhongjing Lin Wangmin Liu Yisheng Zhong |
| author_sort | Shuo Xu |
| collection | DOAJ |
| description | Background. To evaluate the potential diagnostic value of CDI of retrobulbar hemodynamic changes in NTG patients. Methods. Relevant publications which included PSV, EDV, and RI of OA, CRA, NPCA, and TPCA in NTG patients and normal controls measured by CDI were retrieved from the Cochrane Central Register of Controlled Trials, PubMed, the ISI Web of Knowledge, and EMBASE from 1990 to 2014. Subgroup analyses were made based on IOP-lowering medications uses. Result. In OA, there was significant decrease of PSV with moderate heterogeneity (P<0.00001, I2=49%) and significant decrease of EDV with significant heterogeneity (P=0.0005, I2=87%) in NTG patients. In CRA, similar results of PSV (P<0.00001, I2=42%) and EDV (P<0.00001, I2=80%) were detected. Significant decrease of PSV and EDV with significant heterogeneity was also found in both NPCA (P<0.0001, I2=70%; P<0.0001, I2=76%; resp.) and TPCA (P<0.00001, I2=54%; P<0.00001, I2=65%; resp.). Statistically significant increases of RI were found in CRA (P=0.0002, I2=89%) and TPCA (P=0.02, I2=81%) with significant heterogeneities, though RI in OA (P=0.25, I2=94%) and in NPCA (P=0.15, I2=86%) showed no statistical changes with significant heterogeneities. Conclusions. Ischemic change of retrobulbar hemodynamics is one of the important manifestations of NTG. Hemodynamic parameters measured by CDI might be potential diagnostic tools for NTG. |
| format | Article |
| id | doaj-art-9be1450582784d109d0ff2016b526aa7 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-9be1450582784d109d0ff2016b526aa72025-08-20T02:18:27ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/919610919610Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-AnalysisShuo Xu0Shouyue Huang1Zhongjing Lin2Wangmin Liu3Yisheng Zhong4Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, ChinaDepartment of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, ChinaDepartment of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, ChinaHubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, ChinaDepartment of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, ChinaBackground. To evaluate the potential diagnostic value of CDI of retrobulbar hemodynamic changes in NTG patients. Methods. Relevant publications which included PSV, EDV, and RI of OA, CRA, NPCA, and TPCA in NTG patients and normal controls measured by CDI were retrieved from the Cochrane Central Register of Controlled Trials, PubMed, the ISI Web of Knowledge, and EMBASE from 1990 to 2014. Subgroup analyses were made based on IOP-lowering medications uses. Result. In OA, there was significant decrease of PSV with moderate heterogeneity (P<0.00001, I2=49%) and significant decrease of EDV with significant heterogeneity (P=0.0005, I2=87%) in NTG patients. In CRA, similar results of PSV (P<0.00001, I2=42%) and EDV (P<0.00001, I2=80%) were detected. Significant decrease of PSV and EDV with significant heterogeneity was also found in both NPCA (P<0.0001, I2=70%; P<0.0001, I2=76%; resp.) and TPCA (P<0.00001, I2=54%; P<0.00001, I2=65%; resp.). Statistically significant increases of RI were found in CRA (P=0.0002, I2=89%) and TPCA (P=0.02, I2=81%) with significant heterogeneities, though RI in OA (P=0.25, I2=94%) and in NPCA (P=0.15, I2=86%) showed no statistical changes with significant heterogeneities. Conclusions. Ischemic change of retrobulbar hemodynamics is one of the important manifestations of NTG. Hemodynamic parameters measured by CDI might be potential diagnostic tools for NTG.http://dx.doi.org/10.1155/2015/919610 |
| spellingShingle | Shuo Xu Shouyue Huang Zhongjing Lin Wangmin Liu Yisheng Zhong Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis Journal of Ophthalmology |
| title | Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis |
| title_full | Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis |
| title_fullStr | Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis |
| title_full_unstemmed | Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis |
| title_short | Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis |
| title_sort | color doppler imaging analysis of ocular blood flow velocities in normal tension glaucoma patients a meta analysis |
| url | http://dx.doi.org/10.1155/2015/919610 |
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