Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
Objectives: Two of the most common neurodegenerative diseases are Alzheimer's disease and Parkinson's disease. The available treatments for the conditions are few and frequently insufficient to stop their progression. Because of possible neuroprotective, anti-oxidant, anti-apoptotic, neuro...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459325000289 |
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| author | Ahsas Goyal Anshika Kumari Aanchal Verma Vandana Chaudhary Prince Pathak Harlokesh Narayan Yadav |
| author_facet | Ahsas Goyal Anshika Kumari Aanchal Verma Vandana Chaudhary Prince Pathak Harlokesh Narayan Yadav |
| author_sort | Ahsas Goyal |
| collection | DOAJ |
| description | Objectives: Two of the most common neurodegenerative diseases are Alzheimer's disease and Parkinson's disease. The available treatments for the conditions are few and frequently insufficient to stop their progression. Because of possible neuroprotective, anti-oxidant, anti-apoptotic, neuromodulating, anti-inflammatory, and many more qualities, honokiol, a polyphenolic chemical that is derived from magnolia plants, has become a prospective option. Methods: To investigate the potential benefits of Honokiol for neurodegenerative disease treatment and prevention, we searched the PubMed, Google Scholar, and ResearchGate databases till 2024 using MeSH (Medical Subject Heading) terms such as “Honokiol”, “Alzheimer's disease”, “Parkinson's disease”, “Neuroprotective effect”, “Anti-oxidant”, “Anti-inflammatory”, “Anti-apoptotic”, and further related keywords combined with the words “Structure”, “Physicochemical properties”, “Pharmacokinetic”, “Toxicology”. Results: This article reviews the pharmacological effects of honokiol in Alzheimer's and Parkinson's diseases based on in vivo and in vitro research. In preclinical models of Alzheimer's disease, honokiol showed promise in lowering the production of amyloid-beta (Aβ) plaques, phosphorylating tau, and enhancing cognitive performance. Also, honokiol demonstrated promise in preventing the degradation of dopaminergic neurons in Parkinson's disease and improving motor function. Conclusion: Honokiol demonstrated promise in minimizing the degradation of dopaminergic neurons in Parkinson's disease as well as improving motor function. This suggests the possible therapeutic and neuroprotective advantages of honokiol. Given its capacity to regulate important pathological processes such as protein aggregation, neuroinflammation, and oxidative stress, the drug seems to be a promising option for additional clinical investigation. |
| format | Article |
| id | doaj-art-9bdf2796e5904e6ca6bccf8d098bbbaf |
| institution | Kabale University |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-9bdf2796e5904e6ca6bccf8d098bbbaf2025-08-20T03:42:37ZengElsevierBrain Disorders2666-45932025-03-011710020810.1016/j.dscb.2025.100208Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson'sAhsas Goyal0Anshika Kumari1Aanchal Verma2Vandana Chaudhary3Prince Pathak4Harlokesh Narayan Yadav5Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India; Corresponding author at: Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IndiaInstitute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IndiaInstitute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IndiaInstitute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, IndiaAll India Institute of Medical Sciences (AIIMS), New Delhi-110029, IndiaObjectives: Two of the most common neurodegenerative diseases are Alzheimer's disease and Parkinson's disease. The available treatments for the conditions are few and frequently insufficient to stop their progression. Because of possible neuroprotective, anti-oxidant, anti-apoptotic, neuromodulating, anti-inflammatory, and many more qualities, honokiol, a polyphenolic chemical that is derived from magnolia plants, has become a prospective option. Methods: To investigate the potential benefits of Honokiol for neurodegenerative disease treatment and prevention, we searched the PubMed, Google Scholar, and ResearchGate databases till 2024 using MeSH (Medical Subject Heading) terms such as “Honokiol”, “Alzheimer's disease”, “Parkinson's disease”, “Neuroprotective effect”, “Anti-oxidant”, “Anti-inflammatory”, “Anti-apoptotic”, and further related keywords combined with the words “Structure”, “Physicochemical properties”, “Pharmacokinetic”, “Toxicology”. Results: This article reviews the pharmacological effects of honokiol in Alzheimer's and Parkinson's diseases based on in vivo and in vitro research. In preclinical models of Alzheimer's disease, honokiol showed promise in lowering the production of amyloid-beta (Aβ) plaques, phosphorylating tau, and enhancing cognitive performance. Also, honokiol demonstrated promise in preventing the degradation of dopaminergic neurons in Parkinson's disease and improving motor function. Conclusion: Honokiol demonstrated promise in minimizing the degradation of dopaminergic neurons in Parkinson's disease as well as improving motor function. This suggests the possible therapeutic and neuroprotective advantages of honokiol. Given its capacity to regulate important pathological processes such as protein aggregation, neuroinflammation, and oxidative stress, the drug seems to be a promising option for additional clinical investigation.http://www.sciencedirect.com/science/article/pii/S2666459325000289Alzheimer's diseaseHonokiolMagnolia officinalisNeurodegenerationParkinson's disease |
| spellingShingle | Ahsas Goyal Anshika Kumari Aanchal Verma Vandana Chaudhary Prince Pathak Harlokesh Narayan Yadav Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's Brain Disorders Alzheimer's disease Honokiol Magnolia officinalis Neurodegeneration Parkinson's disease |
| title | Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's |
| title_full | Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's |
| title_fullStr | Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's |
| title_full_unstemmed | Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's |
| title_short | Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's |
| title_sort | nature s neuroprotector honokiol and its promise for alzheimer s and parkinson s |
| topic | Alzheimer's disease Honokiol Magnolia officinalis Neurodegeneration Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S2666459325000289 |
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