Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterization
Abstract The objective of this study was to convert homopterocarpin derived from Pterocarpus macrocarpus Kurz. heartwood to medicarpin using Aspergillus niger (strain UI X-172) and assess its antioxidant, antiplasmodial, and anticancer activities in silico and in vitro. This study highlighted biotra...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-06729-9 |
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| author | Dwi Kusuma Wahyuni Sumrit Wacharasindhu Wichanee Bankeeree Hunsa Punnapayak Sastia Prama Putri Sehanat Prasongsuk |
| author_facet | Dwi Kusuma Wahyuni Sumrit Wacharasindhu Wichanee Bankeeree Hunsa Punnapayak Sastia Prama Putri Sehanat Prasongsuk |
| author_sort | Dwi Kusuma Wahyuni |
| collection | DOAJ |
| description | Abstract The objective of this study was to convert homopterocarpin derived from Pterocarpus macrocarpus Kurz. heartwood to medicarpin using Aspergillus niger (strain UI X-172) and assess its antioxidant, antiplasmodial, and anticancer activities in silico and in vitro. This study highlighted biotransformation of homopterocarpin to medicarpin via demethylation. Medicarpin demonstrated antioxidant activity against 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS, IC50 = 0.61 ± 0.05 µg/mL) and 1,1-diphenyl-2-picrylhydrazyl (DPPH, IC50 = 7.50 ± 1.6 µg/mL), antiplasmodial activity against the Plasmodium falciparum strain 3D7 (IC50 = 0.45 ± 0.35 µg/mL), and anticancer efficacy against a hepatocyte-derived carcinoma cell line (Huh7it-1 cells, IC50 = 34.32 ± 5.56 µg/mL). Medicarpin also showed favorable antioxidant, antiplasmodial, and anticancer properties in silico with a binding affinity lower than commercial drugs. These results highlight the green synthesis of medicarpin by microbial transformation using A. niger, which demonstrates promising in vitro and computational activity, however, further studies are required for clinical development. |
| format | Article |
| id | doaj-art-9bdf1897f3a04b4cb0be3d551bd86283 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-9bdf1897f3a04b4cb0be3d551bd862832025-08-20T03:42:45ZengNature PortfolioScientific Reports2045-23222025-07-0115112010.1038/s41598-025-06729-9Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterizationDwi Kusuma Wahyuni0Sumrit Wacharasindhu1Wichanee Bankeeree2Hunsa Punnapayak3Sastia Prama Putri4Sehanat Prasongsuk5Plant Biomass Utilization Research Unit, Department of Botany, Faculty of Science, Chulalongkorn UniversityDepartment of Chemistry, Faculty of Science, Chulalongkorn UniversityPlant Biomass Utilization Research Unit, Department of Botany, Faculty of Science, Chulalongkorn UniversityPlant Biomass Utilization Research Unit, Department of Botany, Faculty of Science, Chulalongkorn UniversityDepartment of Biotechnology, Graduate School of Engineering, Osaka UniversityPlant Biomass Utilization Research Unit, Department of Botany, Faculty of Science, Chulalongkorn UniversityAbstract The objective of this study was to convert homopterocarpin derived from Pterocarpus macrocarpus Kurz. heartwood to medicarpin using Aspergillus niger (strain UI X-172) and assess its antioxidant, antiplasmodial, and anticancer activities in silico and in vitro. This study highlighted biotransformation of homopterocarpin to medicarpin via demethylation. Medicarpin demonstrated antioxidant activity against 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS, IC50 = 0.61 ± 0.05 µg/mL) and 1,1-diphenyl-2-picrylhydrazyl (DPPH, IC50 = 7.50 ± 1.6 µg/mL), antiplasmodial activity against the Plasmodium falciparum strain 3D7 (IC50 = 0.45 ± 0.35 µg/mL), and anticancer efficacy against a hepatocyte-derived carcinoma cell line (Huh7it-1 cells, IC50 = 34.32 ± 5.56 µg/mL). Medicarpin also showed favorable antioxidant, antiplasmodial, and anticancer properties in silico with a binding affinity lower than commercial drugs. These results highlight the green synthesis of medicarpin by microbial transformation using A. niger, which demonstrates promising in vitro and computational activity, however, further studies are required for clinical development.https://doi.org/10.1038/s41598-025-06729-9Aspergillus NigerBiological propertiesBiotransformationHomopterocarpinMedicarpin |
| spellingShingle | Dwi Kusuma Wahyuni Sumrit Wacharasindhu Wichanee Bankeeree Hunsa Punnapayak Sastia Prama Putri Sehanat Prasongsuk Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterization Scientific Reports Aspergillus Niger Biological properties Biotransformation Homopterocarpin Medicarpin |
| title | Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterization |
| title_full | Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterization |
| title_fullStr | Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterization |
| title_full_unstemmed | Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterization |
| title_short | Biotransformation of medicarpin from homopterocarpin by Aspergillus niger and its biological characterization |
| title_sort | biotransformation of medicarpin from homopterocarpin by aspergillus niger and its biological characterization |
| topic | Aspergillus Niger Biological properties Biotransformation Homopterocarpin Medicarpin |
| url | https://doi.org/10.1038/s41598-025-06729-9 |
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