DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS
The new gel-sublimation technique for preparation porus biodegradable scaffolds (hydroxybutyrate-co-hydro- xyvalerate) is presented. The scaffolds with multi-mode internal structure have the of porus sizes varied from ~100 microns up to ~100 nanometers and the porosity in a range of 80–90%. A few te...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2010-06-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/309 |
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| author | V. N. Vasilets L. M. Zaitov A. Y. Milentev S. L. Nedoseev P. V. Shvartskopf V. A. Egorova V. I. Sevastjanov |
| author_facet | V. N. Vasilets L. M. Zaitov A. Y. Milentev S. L. Nedoseev P. V. Shvartskopf V. A. Egorova V. I. Sevastjanov |
| author_sort | V. N. Vasilets |
| collection | DOAJ |
| description | The new gel-sublimation technique for preparation porus biodegradable scaffolds (hydroxybutyrate-co-hydro- xyvalerate) is presented. The scaffolds with multi-mode internal structure have the of porus sizes varied from ~100 microns up to ~100 nanometers and the porosity in a range of 80–90%. A few techniques for modification of 3D scaffolds by gas discharge plasma are developed and optimized: the microsecond dielectric barrier dischar- ge, the semi-self-maintained discharge supported by an electron beam; the nanosecond dielectric barrier dischar- ge. Biological tests including red blood cell hemolysis and cytotoxicity analysis have shown the possibilities of scaffolds applications for cell-based technologies. |
| format | Article |
| id | doaj-art-9bddfac1bf9d4d5f95ada922534d88f9 |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2010-06-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-9bddfac1bf9d4d5f95ada922534d88f92025-08-20T03:44:23ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912010-06-01122677310.15825/1995-1191-2010-2-67-73252DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALSV. N. Vasilets0L. M. Zaitov1A. Y. Milentev2S. L. Nedoseev3P. V. Shvartskopf4V. A. Egorova5V. I. Sevastjanov6Institute of Biomedical Research and Technology, Moscow Institute for Energy Problems of Chemical Physics (Branch), ChernogolovkaRussian Research Center «Kurchatov Institute», MoscowLomonosov State Academy of Fine Chemical Technology, MoscowRussian Research Center «Kurchatov Institute», MoscowMoscow Institute of Physics and Technology, DolgoprudniyAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowThe new gel-sublimation technique for preparation porus biodegradable scaffolds (hydroxybutyrate-co-hydro- xyvalerate) is presented. The scaffolds with multi-mode internal structure have the of porus sizes varied from ~100 microns up to ~100 nanometers and the porosity in a range of 80–90%. A few techniques for modification of 3D scaffolds by gas discharge plasma are developed and optimized: the microsecond dielectric barrier dischar- ge, the semi-self-maintained discharge supported by an electron beam; the nanosecond dielectric barrier dischar- ge. Biological tests including red blood cell hemolysis and cytotoxicity analysis have shown the possibilities of scaffolds applications for cell-based technologies.https://journal.transpl.ru/vtio/article/view/309cell technologiesbiodegradable scaffoldspoly(hydroxybutyrate-co-hydroxyvalerate)gel- sublimation techniquegas discharge plasmahemolysiscytotoxicity |
| spellingShingle | V. N. Vasilets L. M. Zaitov A. Y. Milentev S. L. Nedoseev P. V. Shvartskopf V. A. Egorova V. I. Sevastjanov DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS Вестник трансплантологии и искусственных органов cell technologies biodegradable scaffolds poly(hydroxybutyrate-co-hydroxyvalerate) gel- sublimation technique gas discharge plasma hemolysis cytotoxicity |
| title | DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS |
| title_full | DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS |
| title_fullStr | DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS |
| title_full_unstemmed | DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS |
| title_short | DEVELOPMENT AND BIOLOGICAL TESTING OF NEW SCAFFOLDS FROM BIODEGRADABLE MATERIALS |
| title_sort | development and biological testing of new scaffolds from biodegradable materials |
| topic | cell technologies biodegradable scaffolds poly(hydroxybutyrate-co-hydroxyvalerate) gel- sublimation technique gas discharge plasma hemolysis cytotoxicity |
| url | https://journal.transpl.ru/vtio/article/view/309 |
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