Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes

Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes

ABSTRACT In 2022, a cluster of severe childhood hepatitis was detected primarily in Europe and North America, leading to a global alert by the World Health Organization. An association with adeno-associated virus 2 (AAV2) in conjunction with human adenoviruses was found. Five percent of the cases pr...

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Main Authors: Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
metagenomics
transcriptomics
adeno-associated virus
childhood hepatitis
Online Access:https://journals.asm.org/doi/10.1128/mbio.03913-24
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