BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults
The impacts of thyroid hormones (TH) on lipid profile in euthyroid adults have gained much attention. It is currently unknown whether BMI influences such interaction. In the present study, we investigate the role of BMI in modulating the association between TH and lipid parameters in 1372 euthyroid...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/8591986 |
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| author | Yanqiu Wang Qinglei Yin Min Xu Qicheng Ni Weiqing Wang Qidi Wang |
| author_facet | Yanqiu Wang Qinglei Yin Min Xu Qicheng Ni Weiqing Wang Qidi Wang |
| author_sort | Yanqiu Wang |
| collection | DOAJ |
| description | The impacts of thyroid hormones (TH) on lipid profile in euthyroid adults have gained much attention. It is currently unknown whether BMI influences such interaction. In the present study, we investigate the role of BMI in modulating the association between TH and lipid parameters in 1372 euthyroid healthy adults. Our results show that thyroid parameters are differentially associated with lipid profile. FT3 is positively correlated with total cholesterol (β=0.176±0.046, P<0.001) and LDL cholesterol levels (β=0.161±0.040, P<0.001). FT4 is negatively correlated with TG (β=−0.087±0.029, P<0.01) while positively correlated with HDL cholesterol levels (β=0.013±0.005, P<0.01). TSH is positively associated with TG (β=0.145±0.056, P<0.05) and total cholesterol levels (β=0.094±0.030, P<0.01). Importantly, BMI modulates the effect of TH on lipid profile: the interaction of FT4 and BMI and the interaction of FT3 and BMI reach statistical significance in predicting TG and HDL cholesterol levels, respectively. Stratified according to BMI levels, most associations between TH and lipid profile are significant only in normal-weight group. In conclusion, in euthyroid adults, high normal FT3, TSH levels, and low normal FT4 levels are associated with unfavorable lipid profile. BMI mediates the effect of thyroid function on lipid profile in euthyroid adults. |
| format | Article |
| id | doaj-art-9bda84b31bfb41f1a69ae2ec20f2c467 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-9bda84b31bfb41f1a69ae2ec20f2c4672025-08-20T02:18:25ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/85919868591986BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid AdultsYanqiu Wang0Qinglei Yin1Min Xu2Qicheng Ni3Weiqing Wang4Qidi Wang5Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, ChinaThe impacts of thyroid hormones (TH) on lipid profile in euthyroid adults have gained much attention. It is currently unknown whether BMI influences such interaction. In the present study, we investigate the role of BMI in modulating the association between TH and lipid parameters in 1372 euthyroid healthy adults. Our results show that thyroid parameters are differentially associated with lipid profile. FT3 is positively correlated with total cholesterol (β=0.176±0.046, P<0.001) and LDL cholesterol levels (β=0.161±0.040, P<0.001). FT4 is negatively correlated with TG (β=−0.087±0.029, P<0.01) while positively correlated with HDL cholesterol levels (β=0.013±0.005, P<0.01). TSH is positively associated with TG (β=0.145±0.056, P<0.05) and total cholesterol levels (β=0.094±0.030, P<0.01). Importantly, BMI modulates the effect of TH on lipid profile: the interaction of FT4 and BMI and the interaction of FT3 and BMI reach statistical significance in predicting TG and HDL cholesterol levels, respectively. Stratified according to BMI levels, most associations between TH and lipid profile are significant only in normal-weight group. In conclusion, in euthyroid adults, high normal FT3, TSH levels, and low normal FT4 levels are associated with unfavorable lipid profile. BMI mediates the effect of thyroid function on lipid profile in euthyroid adults.http://dx.doi.org/10.1155/2017/8591986 |
| spellingShingle | Yanqiu Wang Qinglei Yin Min Xu Qicheng Ni Weiqing Wang Qidi Wang BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults International Journal of Endocrinology |
| title | BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults |
| title_full | BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults |
| title_fullStr | BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults |
| title_full_unstemmed | BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults |
| title_short | BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults |
| title_sort | bmi modulates the effect of thyroid hormone on lipid profile in euthyroid adults |
| url | http://dx.doi.org/10.1155/2017/8591986 |
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