Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology
Introduction. Polymer nanoparticles are a key tool to deliver drugs to specific sites and to increase drug bioavailability. Aim. This research aims to use poly amide-disulfide nanoparticles as drug delivery systems. Method. Amlodipine (Amlop) was used as a model, forming Amlop-polymer nanocomposites...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2022/3427400 |
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| author | Zain Alabden Ghanim Ahmed Samer Hasan Hussein-Al-Ali Ibrahim Abdel Aziz Ibrahim Mike Kh. Haddad Dalia Khalil Ali Anwar Mahmoud Hussein Ahmad Adnan Abu Sharar |
| author_facet | Zain Alabden Ghanim Ahmed Samer Hasan Hussein-Al-Ali Ibrahim Abdel Aziz Ibrahim Mike Kh. Haddad Dalia Khalil Ali Anwar Mahmoud Hussein Ahmad Adnan Abu Sharar |
| author_sort | Zain Alabden Ghanim Ahmed |
| collection | DOAJ |
| description | Introduction. Polymer nanoparticles are a key tool to deliver drugs to specific sites and to increase drug bioavailability. Aim. This research aims to use poly amide-disulfide nanoparticles as drug delivery systems. Method. Amlodipine (Amlop) was used as a model, forming Amlop-polymer nanocomposites. In this work, we investigated the effect of independent variables (polymer, Fe3+, Al3+, and pH) on the dependent variables (loading efficiency (%LE), zeta potential, and particle size). Nanocomposites were prepared by an inotropic method. Nanocomposites were characterized by powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), and a release study. Results. From the XRD data, the Amlop-polymer nanocomposite shows semi crystallinity. In addition, the disappearance of drug peaks indicates that the drug was incorporated between the polymer molecules and was amorphous in behavior. The FTIR for the nanocomposite shows the functional group of the drug, which indicates the incorporation of Amlop into the nanocomposite. From FE-SEM, the results showed that our nanocomposites have an average particle size of approximately 130 nm. The release of amlodipine from the Amlop-polymer nanocomposite was found to be controlled, with approximately 85% within approximately 24 hours. Conclusion. The amide-disulfide polymer nanoparticles are promising carriers for different types of drugs. |
| format | Article |
| id | doaj-art-9bda5cb4714c4fcaaa3c8865d50551f7 |
| institution | Kabale University |
| issn | 1687-9430 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-9bda5cb4714c4fcaaa3c8865d50551f72025-02-03T01:23:34ZengWileyInternational Journal of Polymer Science1687-94302022-01-01202210.1155/2022/3427400Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface MethodologyZain Alabden Ghanim Ahmed0Samer Hasan Hussein-Al-Ali1Ibrahim Abdel Aziz Ibrahim2Mike Kh. Haddad3Dalia Khalil Ali4Anwar Mahmoud Hussein5Ahmad Adnan Abu Sharar6Department of Basic Pharmaceutical SciencesDepartment of Basic Pharmaceutical SciencesDepartment of Pharmacology and ToxicologyDepartment of Renewable Energy EngineeringDepartment of Basic Pharmaceutical SciencesDepartment of Basic Pharmaceutical SciencesResearch and Development (R&D) DepartmentIntroduction. Polymer nanoparticles are a key tool to deliver drugs to specific sites and to increase drug bioavailability. Aim. This research aims to use poly amide-disulfide nanoparticles as drug delivery systems. Method. Amlodipine (Amlop) was used as a model, forming Amlop-polymer nanocomposites. In this work, we investigated the effect of independent variables (polymer, Fe3+, Al3+, and pH) on the dependent variables (loading efficiency (%LE), zeta potential, and particle size). Nanocomposites were prepared by an inotropic method. Nanocomposites were characterized by powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), and a release study. Results. From the XRD data, the Amlop-polymer nanocomposite shows semi crystallinity. In addition, the disappearance of drug peaks indicates that the drug was incorporated between the polymer molecules and was amorphous in behavior. The FTIR for the nanocomposite shows the functional group of the drug, which indicates the incorporation of Amlop into the nanocomposite. From FE-SEM, the results showed that our nanocomposites have an average particle size of approximately 130 nm. The release of amlodipine from the Amlop-polymer nanocomposite was found to be controlled, with approximately 85% within approximately 24 hours. Conclusion. The amide-disulfide polymer nanoparticles are promising carriers for different types of drugs.http://dx.doi.org/10.1155/2022/3427400 |
| spellingShingle | Zain Alabden Ghanim Ahmed Samer Hasan Hussein-Al-Ali Ibrahim Abdel Aziz Ibrahim Mike Kh. Haddad Dalia Khalil Ali Anwar Mahmoud Hussein Ahmad Adnan Abu Sharar Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology International Journal of Polymer Science |
| title | Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology |
| title_full | Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology |
| title_fullStr | Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology |
| title_full_unstemmed | Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology |
| title_short | Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology |
| title_sort | development and evaluation of amlodipine polymer nanocomposites using response surface methodology |
| url | http://dx.doi.org/10.1155/2022/3427400 |
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