Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and Determinants
Background. Diastolic dysfunction is common among dialysis patients and is associated with increased morbidity and mortality. Novel echocardiographic speckle tracking strain analysis permits accurate assessment of left ventricular diastolic function, independent of loading conditions and taking all...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/963504 |
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| author | Mihály K. de Bie Nina Ajmone Marsan André Gaasbeek Jeroen J. Bax Marc Groeneveld Bas A. Gabreels Victoria Delgado Ton J. Rabelink Martin J. Schalij J. Wouter Jukema |
| author_facet | Mihály K. de Bie Nina Ajmone Marsan André Gaasbeek Jeroen J. Bax Marc Groeneveld Bas A. Gabreels Victoria Delgado Ton J. Rabelink Martin J. Schalij J. Wouter Jukema |
| author_sort | Mihály K. de Bie |
| collection | DOAJ |
| description | Background. Diastolic dysfunction is common among dialysis patients and is associated with increased morbidity and mortality. Novel echocardiographic speckle tracking strain analysis permits accurate assessment of left ventricular diastolic function, independent of loading conditions and taking all myocardial segments into account. The aim of the study was to evaluate the prevalence of diastolic dysfunction in chronic dialysis patients using this novel technique, and to identify its determinants among clinical and echocardiographic variables. Methods. Patients currently enrolled in the ICD2 study protocol were included for this analysis. Next to conventional echo measurements diastolic function was also assessed by global diastolic strain rate during isovolumic relaxation (SRIVR). Results. A total of 77 patients were included (age 67±8 years, 74% male). When defined as E/SRIVR ≥236, the prevalence of diastolic dysfunction was higher compared to more conventional measurements (48% versus 39%). Left ventricular mass (OR 1.02, 95% CI 1.00–1.04, P=0.014) and pulse wave velocity (OR 1.34, 95% CI 1.07–1.68, P=0.01) were independent determinants of diastolic dysfunction. Conclusion. Diastolic dysfunction is highly prevalent among dialysis patients and might be underestimated using conventional measurements. Left ventricular mass and pulse wave velocity were the only determinants of diastolic dysfunction in these patients. |
| format | Article |
| id | doaj-art-9bd311c7fda14ab792f3ea8ba93d6072 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-9bd311c7fda14ab792f3ea8ba93d60722025-08-20T03:37:31ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/963504963504Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and DeterminantsMihály K. de Bie0Nina Ajmone Marsan1André Gaasbeek2Jeroen J. Bax3Marc Groeneveld4Bas A. Gabreels5Victoria Delgado6Ton J. Rabelink7Martin J. Schalij8J. Wouter Jukema9Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Nephrology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Nephrology, Medisch Centrum Haagland, 2125 VA, The Hague, The NetherlandsDepartment of Nephrology, Rijnland Ziekenhuis, Leiderdorp, The NetherlandsDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Nephrology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsBackground. Diastolic dysfunction is common among dialysis patients and is associated with increased morbidity and mortality. Novel echocardiographic speckle tracking strain analysis permits accurate assessment of left ventricular diastolic function, independent of loading conditions and taking all myocardial segments into account. The aim of the study was to evaluate the prevalence of diastolic dysfunction in chronic dialysis patients using this novel technique, and to identify its determinants among clinical and echocardiographic variables. Methods. Patients currently enrolled in the ICD2 study protocol were included for this analysis. Next to conventional echo measurements diastolic function was also assessed by global diastolic strain rate during isovolumic relaxation (SRIVR). Results. A total of 77 patients were included (age 67±8 years, 74% male). When defined as E/SRIVR ≥236, the prevalence of diastolic dysfunction was higher compared to more conventional measurements (48% versus 39%). Left ventricular mass (OR 1.02, 95% CI 1.00–1.04, P=0.014) and pulse wave velocity (OR 1.34, 95% CI 1.07–1.68, P=0.01) were independent determinants of diastolic dysfunction. Conclusion. Diastolic dysfunction is highly prevalent among dialysis patients and might be underestimated using conventional measurements. Left ventricular mass and pulse wave velocity were the only determinants of diastolic dysfunction in these patients.http://dx.doi.org/10.1155/2012/963504 |
| spellingShingle | Mihály K. de Bie Nina Ajmone Marsan André Gaasbeek Jeroen J. Bax Marc Groeneveld Bas A. Gabreels Victoria Delgado Ton J. Rabelink Martin J. Schalij J. Wouter Jukema Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and Determinants International Journal of Nephrology |
| title | Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and Determinants |
| title_full | Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and Determinants |
| title_fullStr | Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and Determinants |
| title_full_unstemmed | Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and Determinants |
| title_short | Left Ventricular Diastolic Dysfunction in Dialysis Patients Assessed by Novel Speckle Tracking Strain Rate Analysis: Prevalence and Determinants |
| title_sort | left ventricular diastolic dysfunction in dialysis patients assessed by novel speckle tracking strain rate analysis prevalence and determinants |
| url | http://dx.doi.org/10.1155/2012/963504 |
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