Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India
Background: Acute Undifferentiated Fever (AUF) is a common clinical presentation at hospitals in tropical and subtropical countries. Both children and adults present with this clinical condition which is difficult to diagnose clinically and has infectious and non-infectious causes. Early and accurat...
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Elsevier
2025-07-01
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| Series: | Clinical Epidemiology and Global Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398425001526 |
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| author | Sara Chandy Divya Narayanan Anand Manoharan Vignesh Moorthy Gowridevi Vankayala Hemalatha Ramachandran Rohitha Chandra |
| author_facet | Sara Chandy Divya Narayanan Anand Manoharan Vignesh Moorthy Gowridevi Vankayala Hemalatha Ramachandran Rohitha Chandra |
| author_sort | Sara Chandy |
| collection | DOAJ |
| description | Background: Acute Undifferentiated Fever (AUF) is a common clinical presentation at hospitals in tropical and subtropical countries. Both children and adults present with this clinical condition which is difficult to diagnose clinically and has infectious and non-infectious causes. Early and accurate diagnosis of AUF requires good diagnostic tools. Dengue remains the most common infectious cause of AUF in India, followed by scrub typhus. All the four dengue serotypes (DEN1, DEN2, DEN3 and DEN4) cause disease in children and adults with clinical presentation ranging from febrile illness to severe dengue manifested as shock and multi-organ failure. Methods: This study, done in South India, explores the dengue burden in AUF cases, dominant serotypes, and their clinical manifestations. Results: Our study indicates that from 2022 to 2023, DEN2 remained the most common circulating serotype closely followed by DEN3. DEN3 is emerging fast and likely to become the most predominant serotype in Chennai. Conclusion: Multiplex real time PCR is currently accepted as an affordable and sensitive tool for diagnosis of infectious causes of AUF. Serotype surveillance is important for controlling outbreaks and for clinical management of pediatric patients. |
| format | Article |
| id | doaj-art-9bcedc49c29d4355a3784441e0a15dd2 |
| institution | DOAJ |
| issn | 2213-3984 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj-art-9bcedc49c29d4355a3784441e0a15dd22025-08-20T03:14:01ZengElsevierClinical Epidemiology and Global Health2213-39842025-07-013410206310.1016/j.cegh.2025.102063Association between dengue and pediatric AUF: A study from Chennai and Kochi, South IndiaSara Chandy0Divya Narayanan1Anand Manoharan2Vignesh Moorthy3Gowridevi Vankayala4Hemalatha Ramachandran5Rohitha Chandra6The CHILDS Trust Medical Research Foundation, 12 A, Nageswara Rd, Tirumurthy Nagar, Nungambakkam, Chennai, India; Corresponding author.Kanchi Kamakoti Childs Trust Hospital, 12 A, Nageswara Rd, Tirumurthy Nagar, Nungambakkam, Chennai, IndiaGlaxo Smith Kline (GSK), 252, Dr. Annie Besant Road, Worli, Mumbai, Maharashtra, IndiaThe CHILDS Trust Medical Research Foundation, 12 A, Nageswara Rd, Tirumurthy Nagar, Nungambakkam, Chennai, IndiaThe CHILDS Trust Medical Research Foundation, 12 A, Nageswara Rd, Tirumurthy Nagar, Nungambakkam, Chennai, IndiaKanchi Kamakoti Childs Trust Hospital, 12 A, Nageswara Rd, Tirumurthy Nagar, Nungambakkam, Chennai, IndiaLisie Hospital, Lisie Hospital Rd, North Kaloor, Kaloor, Ernakulam, Kerala, IndiaBackground: Acute Undifferentiated Fever (AUF) is a common clinical presentation at hospitals in tropical and subtropical countries. Both children and adults present with this clinical condition which is difficult to diagnose clinically and has infectious and non-infectious causes. Early and accurate diagnosis of AUF requires good diagnostic tools. Dengue remains the most common infectious cause of AUF in India, followed by scrub typhus. All the four dengue serotypes (DEN1, DEN2, DEN3 and DEN4) cause disease in children and adults with clinical presentation ranging from febrile illness to severe dengue manifested as shock and multi-organ failure. Methods: This study, done in South India, explores the dengue burden in AUF cases, dominant serotypes, and their clinical manifestations. Results: Our study indicates that from 2022 to 2023, DEN2 remained the most common circulating serotype closely followed by DEN3. DEN3 is emerging fast and likely to become the most predominant serotype in Chennai. Conclusion: Multiplex real time PCR is currently accepted as an affordable and sensitive tool for diagnosis of infectious causes of AUF. Serotype surveillance is important for controlling outbreaks and for clinical management of pediatric patients.http://www.sciencedirect.com/science/article/pii/S2213398425001526Pediatric AUFDengueCirculating dengue serotypes |
| spellingShingle | Sara Chandy Divya Narayanan Anand Manoharan Vignesh Moorthy Gowridevi Vankayala Hemalatha Ramachandran Rohitha Chandra Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India Clinical Epidemiology and Global Health Pediatric AUF Dengue Circulating dengue serotypes |
| title | Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India |
| title_full | Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India |
| title_fullStr | Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India |
| title_full_unstemmed | Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India |
| title_short | Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India |
| title_sort | association between dengue and pediatric auf a study from chennai and kochi south india |
| topic | Pediatric AUF Dengue Circulating dengue serotypes |
| url | http://www.sciencedirect.com/science/article/pii/S2213398425001526 |
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