Innovations in the localization techniques for non-palpable breast lesions: Make invisible visible

Non-palpable breast cancer lesions pose a challenge for surgeons to resect cancer lesions. Making ‘invisible’ lesions ‘visible’ is the main strategy. Currently, multiple preoperative localization techniques have been applied in clinical. Among them, wire-guided localization (WGL) is the most common...

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Main Authors: Quankun Lin, Qiwen Hou, Chenyu Zhang, Wei Zhai, Feng Cheng, Sen Lu, Xuan Yang, Aiping Dong, Baosan Han
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Breast
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Online Access:http://www.sciencedirect.com/science/article/pii/S0960977625000499
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author Quankun Lin
Qiwen Hou
Chenyu Zhang
Wei Zhai
Feng Cheng
Sen Lu
Xuan Yang
Aiping Dong
Baosan Han
author_facet Quankun Lin
Qiwen Hou
Chenyu Zhang
Wei Zhai
Feng Cheng
Sen Lu
Xuan Yang
Aiping Dong
Baosan Han
author_sort Quankun Lin
collection DOAJ
description Non-palpable breast cancer lesions pose a challenge for surgeons to resect cancer lesions. Making ‘invisible’ lesions ‘visible’ is the main strategy. Currently, multiple preoperative localization techniques have been applied in clinical. Among them, wire-guided localization (WGL) is the most common procedure due to its convenience and low cost. However, its limitations including discomfort, wire migration and the coupling of localization and operation procedures cause troubles for surgeons and patients. The desire for localization methods improvement, accompanied by the advance of emerging science and technology, leads to the development of a series of locating approaches for breast non-palpable lesions, aiming to improve locating accuracy while reducing adverse events. These emerging methods have undergone improvements from steel wire to functional particles, from radioactivity to non-radioactive, which help doctors and patients choose a more appropriate scheme. This review outlines the principles, procedures, advantages and disadvantages of these locating methods, and highlights the latest progress and related clinical data on innovative locating approaches. Finally, we briefly discuss the current challenges and future opportunities for the clinical application of these localization approaches.
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issn 1532-3080
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series Breast
spelling doaj-art-9bcd799ae7b644fb81c2fb767a2443192025-08-20T03:09:59ZengElsevierBreast1532-30802025-06-018110443010.1016/j.breast.2025.104430Innovations in the localization techniques for non-palpable breast lesions: Make invisible visibleQuankun Lin0Qiwen Hou1Chenyu Zhang2Wei Zhai3Feng Cheng4Sen Lu5Xuan Yang6Aiping Dong7Baosan Han8Department of Breast Surgery, Xinhua Hospital Affiliated of Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, ChinaResearch Center of Breast Tumor Intelligent Diagnosis and Treatment, University of Shanghai for Science and Technology, Shanghai, 200093, ChinaDepartment of Breast Surgery, Xinhua Hospital Affiliated of Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, ChinaResearch Center of Breast Tumor Intelligent Diagnosis and Treatment, University of Shanghai for Science and Technology, Shanghai, 200093, ChinaDepartment of Breast Surgery, Xinhua Hospital Affiliated of Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, ChinaDepartment of Breast Surgery, Xinhua Hospital Affiliated of Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, ChinaResearch Center of Breast Tumor Intelligent Diagnosis and Treatment, University of Shanghai for Science and Technology, Shanghai, 200093, ChinaResearch Center of Breast Tumor Intelligent Diagnosis and Treatment, University of Shanghai for Science and Technology, Shanghai, 200093, ChinaDepartment of Breast Surgery, Xinhua Hospital Affiliated of Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, China; Corresponding author.Non-palpable breast cancer lesions pose a challenge for surgeons to resect cancer lesions. Making ‘invisible’ lesions ‘visible’ is the main strategy. Currently, multiple preoperative localization techniques have been applied in clinical. Among them, wire-guided localization (WGL) is the most common procedure due to its convenience and low cost. However, its limitations including discomfort, wire migration and the coupling of localization and operation procedures cause troubles for surgeons and patients. The desire for localization methods improvement, accompanied by the advance of emerging science and technology, leads to the development of a series of locating approaches for breast non-palpable lesions, aiming to improve locating accuracy while reducing adverse events. These emerging methods have undergone improvements from steel wire to functional particles, from radioactivity to non-radioactive, which help doctors and patients choose a more appropriate scheme. This review outlines the principles, procedures, advantages and disadvantages of these locating methods, and highlights the latest progress and related clinical data on innovative locating approaches. Finally, we briefly discuss the current challenges and future opportunities for the clinical application of these localization approaches.http://www.sciencedirect.com/science/article/pii/S0960977625000499Breast cancerNon-palpable lesionsLocalizationPreoperative localization technique
spellingShingle Quankun Lin
Qiwen Hou
Chenyu Zhang
Wei Zhai
Feng Cheng
Sen Lu
Xuan Yang
Aiping Dong
Baosan Han
Innovations in the localization techniques for non-palpable breast lesions: Make invisible visible
Breast
Breast cancer
Non-palpable lesions
Localization
Preoperative localization technique
title Innovations in the localization techniques for non-palpable breast lesions: Make invisible visible
title_full Innovations in the localization techniques for non-palpable breast lesions: Make invisible visible
title_fullStr Innovations in the localization techniques for non-palpable breast lesions: Make invisible visible
title_full_unstemmed Innovations in the localization techniques for non-palpable breast lesions: Make invisible visible
title_short Innovations in the localization techniques for non-palpable breast lesions: Make invisible visible
title_sort innovations in the localization techniques for non palpable breast lesions make invisible visible
topic Breast cancer
Non-palpable lesions
Localization
Preoperative localization technique
url http://www.sciencedirect.com/science/article/pii/S0960977625000499
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