Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After Study
Introduction: Cushing disease is a rare problem that usually has an important effect on the quality of life (QoL). Objective: This survey aimed to evaluate patients’ QoL and determine predictors of improving QoL scores in patients. Materials and Methods: In this before-after study, basic character...
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| Format: | Article |
| Language: | English |
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Guilan University of Medical Sciences
2023-03-01
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| Series: | Journal of Holistic Nursing and Midwifery |
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| Online Access: | http://hnmj.gums.ac.ir/article-1-2071-en.pdf |
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| author | Arezoo Chouhdari Omidvar Rezaei Mohammad Samadian Guive Sharifi Kaveh Ebrahimzadeh Zahra Davoudi |
| author_facet | Arezoo Chouhdari Omidvar Rezaei Mohammad Samadian Guive Sharifi Kaveh Ebrahimzadeh Zahra Davoudi |
| author_sort | Arezoo Chouhdari |
| collection | DOAJ |
| description | Introduction: Cushing disease is a rare problem that usually has an important effect on the quality of life (QoL).
Objective: This survey aimed to evaluate patients’ QoL and determine predictors of improving QoL scores in patients.
Materials and Methods: In this before-after study, basic characteristics were collected from 56 patients with Cushing disease who underwent endoscopic transsphenoidal surgery, and their QoL score during one year was assessed. Finally, predictor factors of QoL score improvement were identified. To compare the QoL scores before, 6 months, and 12 months after surgery, repeated measures ANOVA and for determining predictors of QoL score improvement, multivariable logistic regression analysis was used. P<0.05 was considered significant in all tests.
Results: The Mean±SD age of the samples was 33.92±12.82 years, and 43 (76.8%) were female. In all 56 patients who underwent endoscopic transsphenoidal surgery, the QoL score significantly improved. In multivariable logistic regression analysis, weight loss (OR= 1.2, 95% CI; 1.01-6.5, P=0.01), no fatigue (OR= 2.1, 95%CI; 1.6-8.3, P=0.009), no decreased libido (OR= 1.5, 95% CI; 1.2-10.62, P=0.01), no gonadal axis disorder (OR=2.2, 95% CI; 1.07-4.06, P=0.01) and post-operation no thyroid axis disorder (OR=2.5, 95% CI; 1.8-5.7, P=0.01) were predictors for more QoL score improvement.
Conclusion: According to the results of this study, many factors can affect the quality of life in patients with Cushing disease. Therefore, support groups should include the cooperation of physicians and psychologists, provision of health services, and social support to improve the QoL of patients. |
| format | Article |
| id | doaj-art-9bc894bd6c7148c5a759498d8ecb152c |
| institution | Kabale University |
| issn | 2588-3712 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Journal of Holistic Nursing and Midwifery |
| spelling | doaj-art-9bc894bd6c7148c5a759498d8ecb152c2025-08-20T03:41:49ZengGuilan University of Medical SciencesJournal of Holistic Nursing and Midwifery2588-37122023-03-01332159169Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After StudyArezoo Chouhdari0Omidvar Rezaei1Mohammad Samadian2Guive Sharifi3Kaveh Ebrahimzadeh4Zahra Davoudi5 Assistant Professor, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Social Determinants of Health Research Center (SDHRC), Amir-al-Momenin Hospital, Tehran Medical Sciences Branch, Tehran, Iran Professor, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Professor, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Professor, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Assistant Professor, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Assistant Professor, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Introduction: Cushing disease is a rare problem that usually has an important effect on the quality of life (QoL). Objective: This survey aimed to evaluate patients’ QoL and determine predictors of improving QoL scores in patients. Materials and Methods: In this before-after study, basic characteristics were collected from 56 patients with Cushing disease who underwent endoscopic transsphenoidal surgery, and their QoL score during one year was assessed. Finally, predictor factors of QoL score improvement were identified. To compare the QoL scores before, 6 months, and 12 months after surgery, repeated measures ANOVA and for determining predictors of QoL score improvement, multivariable logistic regression analysis was used. P<0.05 was considered significant in all tests. Results: The Mean±SD age of the samples was 33.92±12.82 years, and 43 (76.8%) were female. In all 56 patients who underwent endoscopic transsphenoidal surgery, the QoL score significantly improved. In multivariable logistic regression analysis, weight loss (OR= 1.2, 95% CI; 1.01-6.5, P=0.01), no fatigue (OR= 2.1, 95%CI; 1.6-8.3, P=0.009), no decreased libido (OR= 1.5, 95% CI; 1.2-10.62, P=0.01), no gonadal axis disorder (OR=2.2, 95% CI; 1.07-4.06, P=0.01) and post-operation no thyroid axis disorder (OR=2.5, 95% CI; 1.8-5.7, P=0.01) were predictors for more QoL score improvement. Conclusion: According to the results of this study, many factors can affect the quality of life in patients with Cushing disease. Therefore, support groups should include the cooperation of physicians and psychologists, provision of health services, and social support to improve the QoL of patients.http://hnmj.gums.ac.ir/article-1-2071-en.pdfquality of life (qol)cushingdisease |
| spellingShingle | Arezoo Chouhdari Omidvar Rezaei Mohammad Samadian Guive Sharifi Kaveh Ebrahimzadeh Zahra Davoudi Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After Study Journal of Holistic Nursing and Midwifery quality of life (qol) cushing disease |
| title | Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After Study |
| title_full | Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After Study |
| title_fullStr | Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After Study |
| title_full_unstemmed | Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After Study |
| title_short | Comparing Quality of Life Before and After Surgery in Patients With Cushing Disease: A Before-After Study |
| title_sort | comparing quality of life before and after surgery in patients with cushing disease a before after study |
| topic | quality of life (qol) cushing disease |
| url | http://hnmj.gums.ac.ir/article-1-2071-en.pdf |
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