A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is a highly aggressive hematological malignancy for which targeted therapies remain underdeveloped. Oncogenic mutations in Notch1 occur in up to 75% of T‐ALL patients. Although γ‐secretase inhibitors (GSIs) can block Notch1 activation, their clini...

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Bibliographic Details
Main Authors: Ruinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
γ‐secretase inhibitors (GSIs)
dihydroartemisinin (DHA)
ferroptosis
T‐cell acute lymphoblastic leukemia (T‐ALL)
Online Access:https://doi.org/10.1002/advs.202505087
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