Interleukin-1 Family Cytokines in Liver Diseases
The gene encoding IL-1 was sequenced more than 30 years ago, and many related cytokines, such as IL-18, IL-33, IL-36, IL-37, IL-38, IL-1 receptor antagonist (IL-1Ra), and IL-36Ra, have since been identified. IL-1 is a potent proinflammatory cytokine and is involved in various inflammatory diseases....
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/630265 |
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| author | Hiroko Tsutsui Xianbin Cai Shuhei Hayashi |
| author_facet | Hiroko Tsutsui Xianbin Cai Shuhei Hayashi |
| author_sort | Hiroko Tsutsui |
| collection | DOAJ |
| description | The gene encoding IL-1 was sequenced more than 30 years ago, and many related cytokines, such as IL-18, IL-33, IL-36, IL-37, IL-38, IL-1 receptor antagonist (IL-1Ra), and IL-36Ra, have since been identified. IL-1 is a potent proinflammatory cytokine and is involved in various inflammatory diseases. Other IL-1 family ligands are critical for the development of diverse diseases, including inflammatory and allergic diseases. Only IL-1Ra possesses the leader peptide required for secretion from cells, and many ligands require posttranslational processing for activation. Some require inflammasome-mediated processing for activation and release, whereas others serve as alarmins and are released following cell membrane rupture, for example, by pyroptosis or necroptosis. Thus, each ligand has the proper molecular process to exert its own biological functions. In this review, we will give a brief introduction to the IL-1 family cytokines and discuss their pivotal roles in the development of various liver diseases in association with immune responses. For example, an excess of IL-33 causes liver fibrosis in mice via activation and expansion of group 2 innate lymphoid cells to produce type 2 cytokines, resulting in cell conversion into pro-fibrotic M2 macrophages. Finally, we will discuss the importance of IL-1 family cytokine-mediated molecular and cellular networks in the development of acute and chronic liver diseases. |
| format | Article |
| id | doaj-art-9bc70095e6894f608b9e5f33c40127c8 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9bc70095e6894f608b9e5f33c40127c82025-08-20T03:36:57ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/630265630265Interleukin-1 Family Cytokines in Liver DiseasesHiroko Tsutsui0Xianbin Cai1Shuhei Hayashi2Department of Microbiology and Department of Pu-Erh Tea and Medical Science, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, JapanDepartment of Microbiology and Department of Pu-Erh Tea and Medical Science, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, JapanDepartment of Microbiology and Department of Pu-Erh Tea and Medical Science, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, JapanThe gene encoding IL-1 was sequenced more than 30 years ago, and many related cytokines, such as IL-18, IL-33, IL-36, IL-37, IL-38, IL-1 receptor antagonist (IL-1Ra), and IL-36Ra, have since been identified. IL-1 is a potent proinflammatory cytokine and is involved in various inflammatory diseases. Other IL-1 family ligands are critical for the development of diverse diseases, including inflammatory and allergic diseases. Only IL-1Ra possesses the leader peptide required for secretion from cells, and many ligands require posttranslational processing for activation. Some require inflammasome-mediated processing for activation and release, whereas others serve as alarmins and are released following cell membrane rupture, for example, by pyroptosis or necroptosis. Thus, each ligand has the proper molecular process to exert its own biological functions. In this review, we will give a brief introduction to the IL-1 family cytokines and discuss their pivotal roles in the development of various liver diseases in association with immune responses. For example, an excess of IL-33 causes liver fibrosis in mice via activation and expansion of group 2 innate lymphoid cells to produce type 2 cytokines, resulting in cell conversion into pro-fibrotic M2 macrophages. Finally, we will discuss the importance of IL-1 family cytokine-mediated molecular and cellular networks in the development of acute and chronic liver diseases.http://dx.doi.org/10.1155/2015/630265 |
| spellingShingle | Hiroko Tsutsui Xianbin Cai Shuhei Hayashi Interleukin-1 Family Cytokines in Liver Diseases Mediators of Inflammation |
| title | Interleukin-1 Family Cytokines in Liver Diseases |
| title_full | Interleukin-1 Family Cytokines in Liver Diseases |
| title_fullStr | Interleukin-1 Family Cytokines in Liver Diseases |
| title_full_unstemmed | Interleukin-1 Family Cytokines in Liver Diseases |
| title_short | Interleukin-1 Family Cytokines in Liver Diseases |
| title_sort | interleukin 1 family cytokines in liver diseases |
| url | http://dx.doi.org/10.1155/2015/630265 |
| work_keys_str_mv | AT hirokotsutsui interleukin1familycytokinesinliverdiseases AT xianbincai interleukin1familycytokinesinliverdiseases AT shuheihayashi interleukin1familycytokinesinliverdiseases |