Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma
The objective of the study: to study rs2227983 polymorphism of EGFR gene in patients with allergic asthma and healthy individuals.Subjects and Methods. 179 patients suffering from allergic asthma were included in the study. The diagnosis and degree of severity were established in accordance with the...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2022-01-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1597 |
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| author | A. B. Аveryanov I. I. Cherkashina S. Yu. Nikulina E. Yu. Kuznetsova V. N. Maksimov |
| author_facet | A. B. Аveryanov I. I. Cherkashina S. Yu. Nikulina E. Yu. Kuznetsova V. N. Maksimov |
| author_sort | A. B. Аveryanov |
| collection | DOAJ |
| description | The objective of the study: to study rs2227983 polymorphism of EGFR gene in patients with allergic asthma and healthy individuals.Subjects and Methods. 179 patients suffering from allergic asthma were included in the study. The diagnosis and degree of severity were established in accordance with the GINA recommendations. The Control Group included apparently healthy individuals (n = 217). Patients with allergic asthma underwent standard laboratory and instrumental examinations and DNA typing.Results. A statistically significant predominance of AG genotype frequency in the group of patients with allergic asthma, including women, versus the group of healthy individuals, was established. AG rs2227983 genotype of EGFR gene was found to be significantly more common in patients with mild and moderate allergic asthma including women, than in healthy individuals, including women.Conclusion. The association of rs2227983 polymorphism of EGFR gene with allergic asthma has been established. A homozygous GG genotype may play a protective role against the disease. |
| format | Article |
| id | doaj-art-9bc66f90ab68413bb5a6e239c7730bdb |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2022-01-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-9bc66f90ab68413bb5a6e239c7730bdb2025-08-20T02:15:59ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062022-01-019912384310.21292/2075-1230-2021-99-12-38-431592Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthmaA. B. Аveryanov0I. I. Cherkashina1S. Yu. Nikulina2E. Yu. Kuznetsova3V. N. Maksimov4V. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityV. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityV. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityV. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityInstitute of Internal and Preventive Medicine, the Branch of Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of SciencesThe objective of the study: to study rs2227983 polymorphism of EGFR gene in patients with allergic asthma and healthy individuals.Subjects and Methods. 179 patients suffering from allergic asthma were included in the study. The diagnosis and degree of severity were established in accordance with the GINA recommendations. The Control Group included apparently healthy individuals (n = 217). Patients with allergic asthma underwent standard laboratory and instrumental examinations and DNA typing.Results. A statistically significant predominance of AG genotype frequency in the group of patients with allergic asthma, including women, versus the group of healthy individuals, was established. AG rs2227983 genotype of EGFR gene was found to be significantly more common in patients with mild and moderate allergic asthma including women, than in healthy individuals, including women.Conclusion. The association of rs2227983 polymorphism of EGFR gene with allergic asthma has been established. A homozygous GG genotype may play a protective role against the disease.https://www.tibl-journal.com/jour/article/view/1597single-nucleotide gene polymorphismbronchial asthmaepidermal growth factor receptorrs2227983 egfr gene |
| spellingShingle | A. B. Аveryanov I. I. Cherkashina S. Yu. Nikulina E. Yu. Kuznetsova V. N. Maksimov Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma Туберкулез и болезни лёгких single-nucleotide gene polymorphism bronchial asthma epidermal growth factor receptor rs2227983 egfr gene |
| title | Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma |
| title_full | Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma |
| title_fullStr | Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma |
| title_full_unstemmed | Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma |
| title_short | Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma |
| title_sort | evaluation of the role of rs2227983 polymorphism of egfr gene in the development of allergic asthma |
| topic | single-nucleotide gene polymorphism bronchial asthma epidermal growth factor receptor rs2227983 egfr gene |
| url | https://www.tibl-journal.com/jour/article/view/1597 |
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