Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological study
Background: Fine needle aspiration cytology (FNAC) is an accurate, reliable, minimally invasive, and cost-effective procedure for pre-operative evaluation of salivary gland lesions. Salivary glands are host to a wide range of pathological conditions ranging from reactive, inflammatory, and cystic co...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2025-03-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4361 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850184146276581376 |
|---|---|
| author | Rajashree Pradhan Sajeeb Mondal Chirasri Goswami Suman Chatterjee |
| author_facet | Rajashree Pradhan Sajeeb Mondal Chirasri Goswami Suman Chatterjee |
| author_sort | Rajashree Pradhan |
| collection | DOAJ |
| description | Background: Fine needle aspiration cytology (FNAC) is an accurate, reliable, minimally invasive, and cost-effective procedure for pre-operative evaluation of salivary gland lesions. Salivary glands are host to a wide range of pathological conditions ranging from reactive, inflammatory, and cystic conditions to neoplastic lesions. In comparison to the epithelial lesions, salivary gland lymphoepithelial lesions (LELs) are rare. Cytological evaluation of the salivary gland LELs was described as case reports in few literatures.
Aims and Objectives: The current study aimed to discuss cytological features of the LELs of the salivary gland elaborately.
Materials and Methods: The study was conducted over a period of 5 years in which a total of 720 salivary gland FNAC samples along with their clinical presentations were studied. LELs were diagnosed in 36 cases.
Results: Out of these lymphoepithelial cysts were diagnosed in 5 cases (13.88%), lymphoepithelial sialadenitis in 16 (44.44%), suggestive of lymphoepithelial carcinoma in 2 (5.5%), and lymphoepithelial sialadenitis with close differential diagnosis such as chronic sclerosing sialadenitis (7,19.44%), Warthin’s tumor (4,10.11%), and low-grade lymphoma in rest of the cases (2,5.5%).
Conclusion: LELs are rare lesions of the salivary gland characterized by lymphocyte infiltration into the salivary parenchyma with associated salivary ductal epithelial cell proliferation. These lesions include reactive non-neoplastic lesions to benign and malignant lesions whose clinical significance varies greatly among these lesions. Hence, careful history taking, clinical examination findings, and adequate sampling for cytological evaluation play pivotal role in a conclusive diagnosis preoperatively which leads to better patient management. |
| format | Article |
| id | doaj-art-9bc473ec8ce84d68bc750302784ad3d4 |
| institution | OA Journals |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-9bc473ec8ce84d68bc750302784ad3d42025-08-20T02:17:06ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-03-011638085https://doi.org/10.71152/ajms.v16i3.4361Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological studyRajashree Pradhan 0https://orcid.org/0000-0001-6770-7367Sajeeb Mondal 1https://orcid.org/0000-0002-1597-8584Chirasri Goswami 2https://orcid.org/0009-0003-7194-5837Suman Chatterjee 3https://orcid.org/0009-0005-4383-3365Associate Professor, Department of Pathology, College of Medicine and Sagore Dutta Hospital, West Bengal, India Associate Professor, Department of Pathology, Rampurhat Government Medical College, Rampurhat, West Bengal, India Senior Consultant, Department of Pathologist, Serum Analysis Center (P) LTD, Kolkata, West Bengal, India Assistant Professor, Department of Biochemistry, Rampurhat Government Medical College, Rampurhat, West Bengal, India Background: Fine needle aspiration cytology (FNAC) is an accurate, reliable, minimally invasive, and cost-effective procedure for pre-operative evaluation of salivary gland lesions. Salivary glands are host to a wide range of pathological conditions ranging from reactive, inflammatory, and cystic conditions to neoplastic lesions. In comparison to the epithelial lesions, salivary gland lymphoepithelial lesions (LELs) are rare. Cytological evaluation of the salivary gland LELs was described as case reports in few literatures. Aims and Objectives: The current study aimed to discuss cytological features of the LELs of the salivary gland elaborately. Materials and Methods: The study was conducted over a period of 5 years in which a total of 720 salivary gland FNAC samples along with their clinical presentations were studied. LELs were diagnosed in 36 cases. Results: Out of these lymphoepithelial cysts were diagnosed in 5 cases (13.88%), lymphoepithelial sialadenitis in 16 (44.44%), suggestive of lymphoepithelial carcinoma in 2 (5.5%), and lymphoepithelial sialadenitis with close differential diagnosis such as chronic sclerosing sialadenitis (7,19.44%), Warthin’s tumor (4,10.11%), and low-grade lymphoma in rest of the cases (2,5.5%). Conclusion: LELs are rare lesions of the salivary gland characterized by lymphocyte infiltration into the salivary parenchyma with associated salivary ductal epithelial cell proliferation. These lesions include reactive non-neoplastic lesions to benign and malignant lesions whose clinical significance varies greatly among these lesions. Hence, careful history taking, clinical examination findings, and adequate sampling for cytological evaluation play pivotal role in a conclusive diagnosis preoperatively which leads to better patient management.https://ajmsjournal.info/index.php/AJMS/article/view/4361fine needle aspiration cytology; lymphoepithelial lesions; lymphoepithelial sialadenitis; salivary gland |
| spellingShingle | Rajashree Pradhan Sajeeb Mondal Chirasri Goswami Suman Chatterjee Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological study Asian Journal of Medical Sciences fine needle aspiration cytology; lymphoepithelial lesions; lymphoepithelial sialadenitis; salivary gland |
| title | Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological study |
| title_full | Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological study |
| title_fullStr | Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological study |
| title_full_unstemmed | Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological study |
| title_short | Cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis: A clinicopathological study |
| title_sort | cytological evaluation of lymphoepithelial lesions of the major salivary glands with special reference to lymphoepithelial sialadenitis a clinicopathological study |
| topic | fine needle aspiration cytology; lymphoepithelial lesions; lymphoepithelial sialadenitis; salivary gland |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4361 |
| work_keys_str_mv | AT rajashreepradhan cytologicalevaluationoflymphoepitheliallesionsofthemajorsalivaryglandswithspecialreferencetolymphoepithelialsialadenitisaclinicopathologicalstudy AT sajeebmondal cytologicalevaluationoflymphoepitheliallesionsofthemajorsalivaryglandswithspecialreferencetolymphoepithelialsialadenitisaclinicopathologicalstudy AT chirasrigoswami cytologicalevaluationoflymphoepitheliallesionsofthemajorsalivaryglandswithspecialreferencetolymphoepithelialsialadenitisaclinicopathologicalstudy AT sumanchatterjee cytologicalevaluationoflymphoepitheliallesionsofthemajorsalivaryglandswithspecialreferencetolymphoepithelialsialadenitisaclinicopathologicalstudy |