Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer
Abstract Background Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall 5-year survival rate ranging from 30...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Cell & Bioscience |
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| Online Access: | https://doi.org/10.1186/s13578-025-01349-2 |
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| author | Lanning Bai Xueqian Qian Hui Zhang Yi Yuan Xiaodong Cui Min Cheng Yangyang Han |
| author_facet | Lanning Bai Xueqian Qian Hui Zhang Yi Yuan Xiaodong Cui Min Cheng Yangyang Han |
| author_sort | Lanning Bai |
| collection | DOAJ |
| description | Abstract Background Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall 5-year survival rate ranging from 30 to 50%. Plectin (PLEC), a 500 kDa scaffolding protein, has gained prominence in recent years due to its pivotal role in various cellular biological functions such as cell morphology, migration and adhesion, while the accurate role of PLEC in OC remains elusive. Results In this study, our findings demonstrate that PLEC exerts a positive influence on the progression of OC, encompassing cellular proliferation, migration, invasion, and adhesion both in vitro and in vivo. Conclusions The results providing new insights for the diagnosis and treatment in OC. |
| format | Article |
| id | doaj-art-9bc2fe2f56e341e1b8654d019dc7ec0d |
| institution | Kabale University |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-9bc2fe2f56e341e1b8654d019dc7ec0d2025-02-09T12:56:22ZengBMCCell & Bioscience2045-37012025-02-0115111610.1186/s13578-025-01349-2Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancerLanning Bai0Xueqian Qian1Hui Zhang2Yi Yuan3Xiaodong Cui4Min Cheng5Yangyang Han6School of Basic Medicine Sciences, Shandong Second Medical UniversitySchool of Life Science and Technology, Shandong Second Medical UniversitySchool of Life Science and Technology, Shandong Second Medical UniversitySchool of Life Science and Technology, Shandong Second Medical UniversitySchool of Basic Medicine Sciences, Shandong Second Medical UniversityDepartment of Physiology, Shandong Second Medical UniversitySchool of Life Science and Technology, Shandong Second Medical UniversityAbstract Background Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall 5-year survival rate ranging from 30 to 50%. Plectin (PLEC), a 500 kDa scaffolding protein, has gained prominence in recent years due to its pivotal role in various cellular biological functions such as cell morphology, migration and adhesion, while the accurate role of PLEC in OC remains elusive. Results In this study, our findings demonstrate that PLEC exerts a positive influence on the progression of OC, encompassing cellular proliferation, migration, invasion, and adhesion both in vitro and in vivo. Conclusions The results providing new insights for the diagnosis and treatment in OC.https://doi.org/10.1186/s13578-025-01349-2AdhesionDiagnostic biomarkerOvarian cancerPlectinTherapeutic target |
| spellingShingle | Lanning Bai Xueqian Qian Hui Zhang Yi Yuan Xiaodong Cui Min Cheng Yangyang Han Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer Cell & Bioscience Adhesion Diagnostic biomarker Ovarian cancer Plectin Therapeutic target |
| title | Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer |
| title_full | Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer |
| title_fullStr | Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer |
| title_full_unstemmed | Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer |
| title_short | Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer |
| title_sort | plectin a novel regulator in migration invasion and adhesion of ovarian cancer |
| topic | Adhesion Diagnostic biomarker Ovarian cancer Plectin Therapeutic target |
| url | https://doi.org/10.1186/s13578-025-01349-2 |
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