Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health
Polysaccharide was a class of macromolecular substance with various bioactive functions. Gut symbiotic microorganisms could utilize the polysaccharides from various sources, thus have important impact on human health. Bacteroides represented one of the dominant colonizers in the human gut. The utili...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2022-09-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000404 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557185268187136 |
|---|---|
| author | Jiaobo Cheng Jielun Hu Fang Geng Shaoping Nie |
| author_facet | Jiaobo Cheng Jielun Hu Fang Geng Shaoping Nie |
| author_sort | Jiaobo Cheng |
| collection | DOAJ |
| description | Polysaccharide was a class of macromolecular substance with various bioactive functions. Gut symbiotic microorganisms could utilize the polysaccharides from various sources, thus have important impact on human health. Bacteroides represented one of the dominant colonizers in the human gut. The utilization of polysaccharide by Bacteroides was important for supporting the function and stability of gut microbiota. After the degradation of polysaccharides by Bacteroides, gut microbes could ferment the monosaccharides and oligosaccharides degraded from polysaccharides into some metabolites, such as short-chain fatty acids (SCFAs), amino acids, etc. Among the metabolites, the SCFAs could have beneficial effects on gut health. This review summarized the niches of Bacteroides among gut microbiota, and also described the gene clusters and membrane proteins involved in the utilization processes of polysaccharide by gut Bacteroides. SCFAs could act as energy substrates for intestinal epithelial cells, inhibit histone deacetylases and activate G protein-coupled receptors. In addition, the future perspectives in investigating new degradation pathways for polysaccharide, and using polysaccharides or their metabolites as therapeutic approaches for diseases mediated by the gut dysbiosis were also provided. |
| format | Article |
| id | doaj-art-9bbd6509cabb4608bdd433fbc1e004cd |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-9bbd6509cabb4608bdd433fbc1e004cd2025-02-03T05:38:22ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111511011110Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut healthJiaobo Cheng0Jielun Hu1Fang Geng2Shaoping Nie3State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, ChinaKey Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, ChinaState Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China; Corresponding author at: State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China.Polysaccharide was a class of macromolecular substance with various bioactive functions. Gut symbiotic microorganisms could utilize the polysaccharides from various sources, thus have important impact on human health. Bacteroides represented one of the dominant colonizers in the human gut. The utilization of polysaccharide by Bacteroides was important for supporting the function and stability of gut microbiota. After the degradation of polysaccharides by Bacteroides, gut microbes could ferment the monosaccharides and oligosaccharides degraded from polysaccharides into some metabolites, such as short-chain fatty acids (SCFAs), amino acids, etc. Among the metabolites, the SCFAs could have beneficial effects on gut health. This review summarized the niches of Bacteroides among gut microbiota, and also described the gene clusters and membrane proteins involved in the utilization processes of polysaccharide by gut Bacteroides. SCFAs could act as energy substrates for intestinal epithelial cells, inhibit histone deacetylases and activate G protein-coupled receptors. In addition, the future perspectives in investigating new degradation pathways for polysaccharide, and using polysaccharides or their metabolites as therapeutic approaches for diseases mediated by the gut dysbiosis were also provided.http://www.sciencedirect.com/science/article/pii/S2213453022000404BacteroidesPolysaccharidesDegradationShort-chain fatty acidsGut health |
| spellingShingle | Jiaobo Cheng Jielun Hu Fang Geng Shaoping Nie Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health Food Science and Human Wellness Bacteroides Polysaccharides Degradation Short-chain fatty acids Gut health |
| title | Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health |
| title_full | Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health |
| title_fullStr | Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health |
| title_full_unstemmed | Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health |
| title_short | Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health |
| title_sort | bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health |
| topic | Bacteroides Polysaccharides Degradation Short-chain fatty acids Gut health |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000404 |
| work_keys_str_mv | AT jiaobocheng bacteroidesutilizationfordietarypolysaccharidesandtheirbeneficialeffectsonguthealth AT jielunhu bacteroidesutilizationfordietarypolysaccharidesandtheirbeneficialeffectsonguthealth AT fanggeng bacteroidesutilizationfordietarypolysaccharidesandtheirbeneficialeffectsonguthealth AT shaopingnie bacteroidesutilizationfordietarypolysaccharidesandtheirbeneficialeffectsonguthealth |