Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis
Abstract Background Ulcerative colitis (UC) causes extensive ulceration attributable to intestinal inflammation. This study investigated the effect of past extensive ulcers (PEUs) on fecal calprotectin (FC). Methods This retrospective, single-center, observational study included patients with UC wit...
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BMC
2024-11-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-024-03522-2 |
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| author | Natsuki Ishida Takatoshi Egami Tomohiro Takebe Kenichi Takahashi Yusuke Asai Satoshi Tamura Tomoharu Matsuura Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Takanori Yamada Satoshi Osawa Ken Sugimoto |
| author_facet | Natsuki Ishida Takatoshi Egami Tomohiro Takebe Kenichi Takahashi Yusuke Asai Satoshi Tamura Tomoharu Matsuura Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Takanori Yamada Satoshi Osawa Ken Sugimoto |
| author_sort | Natsuki Ishida |
| collection | DOAJ |
| description | Abstract Background Ulcerative colitis (UC) causes extensive ulceration attributable to intestinal inflammation. This study investigated the effect of past extensive ulcers (PEUs) on fecal calprotectin (FC). Methods This retrospective, single-center, observational study included patients with UC with a Mayo endoscopic subscore of 0. UC with scarring or pseudopolyposis was defined as PEU and FC and fecal immunochemical occult blood test (FIT) values were compared. The marker levels of patients in the PEU and non-PEU groups were examined to assess clinical relapse within 12 months. Results Of the 61 included patients, 27 had UC with PEUs and 34 had UC without PEUs. Albumin, hemoglobin, and FIT values between groups were not significantly different; however, the C-reactive protein and FC values of the PEU group were significantly higher than those of the non-PEU group. The FC values of the clinical relapse and remission groups within 12 months differed significantly. The cutoff values for the prediction of relapse within 12 months for all patients (area under the curve [AUC], 0.709; 95% confidence interval [CI], 0.512–0.907) and the non-PEU group (AUC, 0.893; 95% CI, 0.724–1.000) were both 118 mg/kg. Conclusions UC patients with PEUs have higher FC values than those without PEUs, even in remission. Additionally, FC values do not predict relapse in PEU patients. Therefore, FC may not be a sufficiently accurate biomarker for patients with PEUs. |
| format | Article |
| id | doaj-art-9bb92a84fbbc43b9a3dd0cf07024b950 |
| institution | OA Journals |
| issn | 1471-230X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-9bb92a84fbbc43b9a3dd0cf07024b9502025-08-20T02:08:23ZengBMCBMC Gastroenterology1471-230X2024-11-012411910.1186/s12876-024-03522-2Effect of past extensive ulcers on fecal calprotectin in ulcerative colitisNatsuki Ishida0Takatoshi Egami1Tomohiro Takebe2Kenichi Takahashi3Yusuke Asai4Satoshi Tamura5Tomoharu Matsuura6Mihoko Yamade7Moriya Iwaizumi8Yasushi Hamaya9Takanori Yamada10Satoshi Osawa11Ken Sugimoto12First Department of Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineDepartment of Laboratory Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineDepartment of Laboratory Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineDepartment of Endoscopic and Photodynamic Medicine, Hamamatsu University School of MedicineDepartment of Endoscopic and Photodynamic Medicine, Hamamatsu University School of MedicineFirst Department of Medicine, Hamamatsu University School of MedicineAbstract Background Ulcerative colitis (UC) causes extensive ulceration attributable to intestinal inflammation. This study investigated the effect of past extensive ulcers (PEUs) on fecal calprotectin (FC). Methods This retrospective, single-center, observational study included patients with UC with a Mayo endoscopic subscore of 0. UC with scarring or pseudopolyposis was defined as PEU and FC and fecal immunochemical occult blood test (FIT) values were compared. The marker levels of patients in the PEU and non-PEU groups were examined to assess clinical relapse within 12 months. Results Of the 61 included patients, 27 had UC with PEUs and 34 had UC without PEUs. Albumin, hemoglobin, and FIT values between groups were not significantly different; however, the C-reactive protein and FC values of the PEU group were significantly higher than those of the non-PEU group. The FC values of the clinical relapse and remission groups within 12 months differed significantly. The cutoff values for the prediction of relapse within 12 months for all patients (area under the curve [AUC], 0.709; 95% confidence interval [CI], 0.512–0.907) and the non-PEU group (AUC, 0.893; 95% CI, 0.724–1.000) were both 118 mg/kg. Conclusions UC patients with PEUs have higher FC values than those without PEUs, even in remission. Additionally, FC values do not predict relapse in PEU patients. Therefore, FC may not be a sufficiently accurate biomarker for patients with PEUs.https://doi.org/10.1186/s12876-024-03522-2Ulcerative colitisFecal calprotectinFecal immunochemical occult blood testPseudopolyposis |
| spellingShingle | Natsuki Ishida Takatoshi Egami Tomohiro Takebe Kenichi Takahashi Yusuke Asai Satoshi Tamura Tomoharu Matsuura Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Takanori Yamada Satoshi Osawa Ken Sugimoto Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis BMC Gastroenterology Ulcerative colitis Fecal calprotectin Fecal immunochemical occult blood test Pseudopolyposis |
| title | Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis |
| title_full | Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis |
| title_fullStr | Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis |
| title_full_unstemmed | Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis |
| title_short | Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis |
| title_sort | effect of past extensive ulcers on fecal calprotectin in ulcerative colitis |
| topic | Ulcerative colitis Fecal calprotectin Fecal immunochemical occult blood test Pseudopolyposis |
| url | https://doi.org/10.1186/s12876-024-03522-2 |
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