HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings
OBJECTIVE: To investigate the association between clinical data, white matter lesions and inflammatory cerebrospinal fluid (CSF) findings in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHOD: We studied brain and cervical spinal cord on magnetic resonance imaging (MRI) and...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2012-04-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400004&lng=en&tlng=en |
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| author | Marzia Puccioni-Sohler Emerson Gasparetto Mauro Jorge Cabral-Castro Carla Slatter Cecilia M. Vidal Romeu Domingues Cortes Bruce R. Rosen Caterina Mainero |
| author_facet | Marzia Puccioni-Sohler Emerson Gasparetto Mauro Jorge Cabral-Castro Carla Slatter Cecilia M. Vidal Romeu Domingues Cortes Bruce R. Rosen Caterina Mainero |
| author_sort | Marzia Puccioni-Sohler |
| collection | DOAJ |
| description | OBJECTIVE: To investigate the association between clinical data, white matter lesions and inflammatory cerebrospinal fluid (CSF) findings in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHOD: We studied brain and cervical spinal cord on magnetic resonance imaging (MRI) and CSF examinations of 28 Brazilian HAM/TSP patients. RESULTS: The majority of patients had severe neurological incapacity with EDSS median of 6.5 (3-8). The brain MRI showed white matter lesions (75%) and atrophy (14%). The preferential brain location was periventricular. Cervical demyelination lesions occurred in 11% of the cases, and cervical atrophy in 3.5%. One patient had enhancement lesions on T1 cervical spinal cord MRI. Cases with spinal cord lesions had signs of acute CSF inflammation. The brain white matter lesions predominated in the patients with higher age. CONCLUSION: Our data suggest that an active inflammatory process is associated with the cervical spinal cord lesions in HAM/TSP. The brain abnormalities are not related to the clinical picture of HAM/TSP. |
| format | Article |
| id | doaj-art-9bb82d6b120048ab989a5b1e6b5cd6e5 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2012-04-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-9bb82d6b120048ab989a5b1e6b5cd6e52025-08-20T03:19:54ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272012-04-0170424625110.1590/S0004-282X2012000400004S0004-282X2012000400004HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findingsMarzia Puccioni-Sohler0Emerson Gasparetto1Mauro Jorge Cabral-Castro2Carla Slatter3Cecilia M. Vidal4Romeu Domingues Cortes5Bruce R. Rosen6Caterina Mainero7Universidade Federal do Rio de JaneiroCenter for Imaging DiagnosisUniversidade Federal do Rio de JaneiroUniversidade Federal do Estado do Rio de JaneiroUniversidade Federal do Estado do Rio de JaneiroHarvard UniversityHarvard UniversityHarvard UniversityOBJECTIVE: To investigate the association between clinical data, white matter lesions and inflammatory cerebrospinal fluid (CSF) findings in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHOD: We studied brain and cervical spinal cord on magnetic resonance imaging (MRI) and CSF examinations of 28 Brazilian HAM/TSP patients. RESULTS: The majority of patients had severe neurological incapacity with EDSS median of 6.5 (3-8). The brain MRI showed white matter lesions (75%) and atrophy (14%). The preferential brain location was periventricular. Cervical demyelination lesions occurred in 11% of the cases, and cervical atrophy in 3.5%. One patient had enhancement lesions on T1 cervical spinal cord MRI. Cases with spinal cord lesions had signs of acute CSF inflammation. The brain white matter lesions predominated in the patients with higher age. CONCLUSION: Our data suggest that an active inflammatory process is associated with the cervical spinal cord lesions in HAM/TSP. The brain abnormalities are not related to the clinical picture of HAM/TSP.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400004&lng=en&tlng=envírus linfotrópico de células T humanas tipo 1mielopatia associa ao HTLV-1líquido cefalorraquidianoimagem por ressonância magnética |
| spellingShingle | Marzia Puccioni-Sohler Emerson Gasparetto Mauro Jorge Cabral-Castro Carla Slatter Cecilia M. Vidal Romeu Domingues Cortes Bruce R. Rosen Caterina Mainero HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings Arquivos de Neuro-Psiquiatria vírus linfotrópico de células T humanas tipo 1 mielopatia associa ao HTLV-1 líquido cefalorraquidiano imagem por ressonância magnética |
| title | HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings |
| title_full | HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings |
| title_fullStr | HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings |
| title_full_unstemmed | HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings |
| title_short | HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings |
| title_sort | ham tsp association between white matter lesions on magnetic resonance imaging clinical and cerebrospinal fluid findings |
| topic | vírus linfotrópico de células T humanas tipo 1 mielopatia associa ao HTLV-1 líquido cefalorraquidiano imagem por ressonância magnética |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400004&lng=en&tlng=en |
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