Structure optimization and molecular dynamics studies of new tumor-selective s-triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers

Structure optimization and molecular dynamics studies of new tumor-selective s-triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers

A series of triazole-tethered triazines bearing pharmacophoric features of DNA-targeting agents and non-hydroxamate MMPs inhibitors were synthesized and screened against HCT-116, Caco-2 cells, and normal colonocytes by MTT assay. 7a and 7g surpassed doxorubicin against HCT-116 cells regarding potenc...

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Bibliographic Details
Main Authors: Christine A. Morcos, Nesreen S. Haiba, Rafik W. Bassily, Marwa M. Abu-Serie, Amira F. El-Yazbi, Omar A. Soliman, Sherine N. Khattab, Mohamed Teleb
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Colorectal cancer
DNA targeting
MMP-10/13 inhibition
1,2,3-triazole-tethered s-triazines
molecular dynamics
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2423174
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