Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering
Articular cartilage is a highly organized tissue with complex biomechanical properties. However, injuries to the cartilage usually lead to numerous health concerns and often culminate in disabling symptoms, due to the poor intrinsic capacity of this tissue for self-healing. Although various approach...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/2030478 |
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| author | Stefano Focaroli Gabriella Teti Viviana Salvatore Isabella Orienti Mirella Falconi |
| author_facet | Stefano Focaroli Gabriella Teti Viviana Salvatore Isabella Orienti Mirella Falconi |
| author_sort | Stefano Focaroli |
| collection | DOAJ |
| description | Articular cartilage is a highly organized tissue with complex biomechanical properties. However, injuries to the cartilage usually lead to numerous health concerns and often culminate in disabling symptoms, due to the poor intrinsic capacity of this tissue for self-healing. Although various approaches are proposed for the regeneration of cartilage, its repair still represents an enormous challenge for orthopedic surgeons. The field of tissue engineering currently offers some of the most promising strategies for cartilage restoration, in which assorted biomaterials and cell-based therapies are combined to develop new therapeutic regimens for tissue replacement. The current study describes the in vitro behavior of human adipose-derived mesenchymal stem cells (hADSCs) encapsulated within calcium/cobalt (Ca/Co) alginate beads. These novel chondrogenesis-promoting scaffolds take advantage of the synergy between the alginate matrix and Co+2 ions, without employing costly growth factors (e.g., transforming growth factor betas (TGF-βs) or bone morphogenetic proteins (BMPs)) to direct hADSC differentiation into cartilage-producing chondrocytes. |
| format | Article |
| id | doaj-art-9b9f576b6e41433483086110e8030b49 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9b9f576b6e41433483086110e8030b492025-02-03T06:44:23ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/20304782030478Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue EngineeringStefano Focaroli0Gabriella Teti1Viviana Salvatore2Isabella Orienti3Mirella Falconi4Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyDepartment of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyArticular cartilage is a highly organized tissue with complex biomechanical properties. However, injuries to the cartilage usually lead to numerous health concerns and often culminate in disabling symptoms, due to the poor intrinsic capacity of this tissue for self-healing. Although various approaches are proposed for the regeneration of cartilage, its repair still represents an enormous challenge for orthopedic surgeons. The field of tissue engineering currently offers some of the most promising strategies for cartilage restoration, in which assorted biomaterials and cell-based therapies are combined to develop new therapeutic regimens for tissue replacement. The current study describes the in vitro behavior of human adipose-derived mesenchymal stem cells (hADSCs) encapsulated within calcium/cobalt (Ca/Co) alginate beads. These novel chondrogenesis-promoting scaffolds take advantage of the synergy between the alginate matrix and Co+2 ions, without employing costly growth factors (e.g., transforming growth factor betas (TGF-βs) or bone morphogenetic proteins (BMPs)) to direct hADSC differentiation into cartilage-producing chondrocytes.http://dx.doi.org/10.1155/2016/2030478 |
| spellingShingle | Stefano Focaroli Gabriella Teti Viviana Salvatore Isabella Orienti Mirella Falconi Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering Stem Cells International |
| title | Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering |
| title_full | Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering |
| title_fullStr | Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering |
| title_full_unstemmed | Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering |
| title_short | Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering |
| title_sort | calcium cobalt alginate beads as functional scaffolds for cartilage tissue engineering |
| url | http://dx.doi.org/10.1155/2016/2030478 |
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