Trimetazidine therapy for diabetic mouse hearts subjected to ex vivo acute heart failure.

Trimetazidine therapy for diabetic mouse hearts subjected to ex vivo acute heart failure.

Acute heart failure (AHF) is the most common primary diagnosis for hospitalized heart diseases in Africa. As increased fatty acid β-oxidation (FAO) during heart failure triggers detrimental effects on the myocardium, we hypothesized that trimetazidine (TMZ) (partial FAO inhibitor) offers cardioprote...

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Bibliographic Details
Main Authors: Emilene Breedt, Lydia Lacerda, M Faadiel Essop
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0179509&type=printable
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