Association of valproate use and hippocampal atrophy in idiopathic generalized epilepsy

Association of valproate use and hippocampal atrophy in idiopathic generalized epilepsy

Objective: Recent studies revealed the effect of valproate (VPA) on brain structural changes in idiopathic generalized epilepsy (IGE). We aimed to investigate the volume of the entire hippocampus and subfields in patients with IGE, and explored their associations with VPA use. Methods: A total of 21...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiang Huang, Yingying Zhang, Qiuxing Lin, Kailing Huang, Yuming Li, Peiwen Liu, Danyang Cao, Wenhao Li, Wei Li, Xiuli Li, Qiyong Gong, Dong Zhou, Dongmei An
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Series:	NeuroImage: Clinical
Subjects:	Valproate Hippocampus Idiopathic Generalized Epilepsy HippUnfold
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213158225000142
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Unveiling Thrombocytopenia Trends In Pediatric Epilepsy: The Valproate Connection
by: Kiran Nayab, et al.
Published: (2025-01-01)

Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis
by: Shasha Huang, et al.
Published: (2025-01-01)

Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats
by: Bonnie H. Lee, et al.
Published: (2025-02-01)

Liminal transformations: folding the surface of the photograph
by: Nour Dados
Published: (2010-04-01)

Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility
by: Nahoko Kuga, et al.
Published: (2025-02-01)

Deep Unfolding-Aided Parameter Tuning for Plug-and-Play-Based Video Snapshot Compressive Imaging
by: Takashi Matsuda, et al.
Published: (2025-01-01)

Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats.
by: Nabirumbi, Ritah, et al.
Published: (2024)

Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy
by: Andy Sitoh, et al.
Published: (2025-02-01)

Spring phenological models combining the effects of temperature and photoperiod are successfully transferred to various spatial and temporal scales: a case study of Aesculus hippocastanum L.
by: Korsakova Svetlana, et al.
Published: (2025-01-01)

Functional segregation of rostral and caudal hippocampus in associative memory
by: Alicia Nunez Vorobiova, et al.
Published: (2025-02-01)

Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s disease
by: Anett Futácsi, et al.
Published: (2025-02-01)

Regulation of adult-born and mature neurons in stress response and antidepressant action in the dentate gyrus of the hippocampus
by: Eri Segi-Nishida, et al.
Published: (2025-02-01)

MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway
by: Qiong Xiang, et al.
Published: (2025-02-01)

Characteristics of beta parapapillary atrophy in primary angle-closure suspect
by: Qing Zhang, et al.
Published: (2024-05-01)

Transmission of unfolded protein response—a regulator of disease progression, severity, and spread in virus infections
by: Vibhu Prasad
Published: (2025-02-01)

Development of therapeutic supplement using roasted-cashew-nut to protect cerebral vasoconstriction injury triggered by mixture of petroleum hydrocarbons in the hypothalamus and hippocampus of rat model
by: J.K. Akintunde, et al.
Published: (2025-06-01)

Resolution of depression: Antidepressant actions of resolvins
by: Satoshi Deyama, et al.
Published: (2025-02-01)

Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients
by: Hongli Wang, et al.
Published: (2025-02-01)

Differences in medial temporal network intrinsic connectivity after a single bout of exercise relate to fitness, memory, and affect
by: Anastasia Cherednichenko, et al.
Published: (2025-02-01)

Causal relationship between lipid profile and muscle atrophy: A bi‐directional Mendelian randomization study
by: Kun Chen, et al.
Published: (2025-01-01)

Biomarkers of gastric atrophy at stomach cancer
by: A. V. Belkovets, et al.
Published: (2018-08-01)

Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway
by: Zhou A, et al.
Published: (2025-02-01)

Mitigating effects of Jiawei Chaihu Shugan decoction on necroptosis and inflammation of hippocampal neurons in epileptic mice
by: Qin Wang, et al.
Published: (2025-02-01)

Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction
by: Jingrun Lin, et al.
Published: (2025-02-01)

Resistance exercise training improves disuse-induced skeletal muscle atrophy in humans: a meta-analysis of randomized controlled trials
by: Xian Guo, et al.
Published: (2025-02-01)

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy
by: Lin Wang, et al.
Published: (2025-02-01)

Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia progression
by: Xun Xu, et al.
Published: (2024-08-01)

Epilepsy care pathway: The Finnish model
by: Reetta Kälviäinen, et al.
Published: (2025-02-01)

The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective
by: Bshra A. Alsfouk, et al.
Published: (2025-02-01)

Clinical characteristics, etiology, and treatment of young adult‐onset epilepsy: A 24‐year retrospective study
by: Xu Zhang, et al.
Published: (2025-02-01)

Mortality in older adults with epilepsy: An understudied entity
by: Syeda Amrah Hashmi, et al.
Published: (2025-02-01)

Marek's disease virus-1 unique gene LORF1 is involved in viral replication and MDV-1/Md5-induced atrophy of the bursa of Fabricius.
by: Chenyi Bao, et al.
Published: (2025-02-01)

Use of Healthcare Claims Data to Generate Real-World Evidence on Patients With Drug-Resistant Epilepsy: Practical Considerations for Research
by: Nicole Stamas, et al.
Published: (2024-02-01)

Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure
by: Blake A. Gimbel, et al.
Published: (2025-02-01)

Progress on responsive neurostimulation in treatment of drug⁃resistant epilepsy
by: FAN Xiu⁃liang, et al.
Published: (2025-01-01)

Healthcare Utilization, Costs of Care, and Mortality Among Patients With Spinal Muscular Atrophy
by: Hiangkiat Tan, et al.
Published: (2019-12-01)

Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy
by: La Dong, et al.
Published: (2025-03-01)

MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity
by: Katy E. Pannoni, et al.
Published: (2025-02-01)

The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradation
by: Quan Yuan, et al.
Published: (2025-01-01)

Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy
by: Mohammad Amin Manavi, et al.
Published: (2025-02-01)