Axon regeneration: an issue of translation
In the mammalian central nervous system (CNS), adult neurons fail to regenerate spontaneously upon axon injury, which leads to a permanent and irreversible loss of neuronal functions. For more than 15 years, much effort was invested to unlock axon regrowth programs based on extensive transcriptomic...
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Académie des sciences
2024-12-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.169/ |
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| author | Schaeffer, Julia Belin, Stephane |
| author_facet | Schaeffer, Julia Belin, Stephane |
| author_sort | Schaeffer, Julia |
| collection | DOAJ |
| description | In the mammalian central nervous system (CNS), adult neurons fail to regenerate spontaneously upon axon injury, which leads to a permanent and irreversible loss of neuronal functions. For more than 15 years, much effort was invested to unlock axon regrowth programs based on extensive transcriptomic characterization. However, it is now well described that mRNA and protein levels correlate only partially in cells, and that the transcription process (from DNA to mRNA) may not directly reflect protein expression. Conversely, the translation process (from mRNA to protein) provides an additional layer of gene regulation. This aspect has been overlooked in CNS regeneration. In this review, we discuss the limitations of transcriptomic approaches to promote CNS regeneration and we provide the rationale to investigate translational regulation in this context, and notably the regulatory role of the translational complex. Finally, we summarize our and others’ recent findings showing how variations in the translational complex composition regulate selective (mRNA-specific) translation, thereby controlling CNS axon regrowth. |
| format | Article |
| id | doaj-art-9b981034ffd5487bb96da9258369c345 |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-9b981034ffd5487bb96da9258369c3452025-02-07T10:37:48ZengAcadémie des sciencesComptes Rendus Biologies1768-32382024-12-01347G124925810.5802/crbiol.16910.5802/crbiol.169Axon regeneration: an issue of translationSchaeffer, Julia0https://orcid.org/0000-0002-1282-5793Belin, Stephane1https://orcid.org/0000-0001-7074-6885Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, FranceUniv. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, FranceIn the mammalian central nervous system (CNS), adult neurons fail to regenerate spontaneously upon axon injury, which leads to a permanent and irreversible loss of neuronal functions. For more than 15 years, much effort was invested to unlock axon regrowth programs based on extensive transcriptomic characterization. However, it is now well described that mRNA and protein levels correlate only partially in cells, and that the transcription process (from DNA to mRNA) may not directly reflect protein expression. Conversely, the translation process (from mRNA to protein) provides an additional layer of gene regulation. This aspect has been overlooked in CNS regeneration. In this review, we discuss the limitations of transcriptomic approaches to promote CNS regeneration and we provide the rationale to investigate translational regulation in this context, and notably the regulatory role of the translational complex. Finally, we summarize our and others’ recent findings showing how variations in the translational complex composition regulate selective (mRNA-specific) translation, thereby controlling CNS axon regrowth.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.169/Axon regenerationTranslation regulationSelective translationTranslational complexRetinal ganglion cellsOptic nerve injury |
| spellingShingle | Schaeffer, Julia Belin, Stephane Axon regeneration: an issue of translation Comptes Rendus Biologies Axon regeneration Translation regulation Selective translation Translational complex Retinal ganglion cells Optic nerve injury |
| title | Axon regeneration: an issue of translation |
| title_full | Axon regeneration: an issue of translation |
| title_fullStr | Axon regeneration: an issue of translation |
| title_full_unstemmed | Axon regeneration: an issue of translation |
| title_short | Axon regeneration: an issue of translation |
| title_sort | axon regeneration an issue of translation |
| topic | Axon regeneration Translation regulation Selective translation Translational complex Retinal ganglion cells Optic nerve injury |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.169/ |
| work_keys_str_mv | AT schaefferjulia axonregenerationanissueoftranslation AT belinstephane axonregenerationanissueoftranslation |