Research status of regenerative difficulties after central nervous system injury
Multiple studies have shown that permanent functional disabilities caused after nerve damage are mainly due to the limited ability of damaged neurons in the central nervous system (CNS) to regenerate axons and re-establish functional connections. Most axons in the CNS of adult mammals cannot reactiv...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425000872 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850274064689528832 |
|---|---|
| author | Yunxia Fu Xi Rui Shumin Zhu Chenqu Guo Haoyang Li Zhenhao Pan Xuanhao Wu Wenpeng He |
| author_facet | Yunxia Fu Xi Rui Shumin Zhu Chenqu Guo Haoyang Li Zhenhao Pan Xuanhao Wu Wenpeng He |
| author_sort | Yunxia Fu |
| collection | DOAJ |
| description | Multiple studies have shown that permanent functional disabilities caused after nerve damage are mainly due to the limited ability of damaged neurons in the central nervous system (CNS) to regenerate axons and re-establish functional connections. Most axons in the CNS of adult mammals cannot reactivate their intrinsic growth program after injury, making axonal regeneration difficult when damaged. This article provides a systematic review of the response processes following CNS injury and the factors affecting repair and regeneration, focusing on the molecular mechanisms that regulate the regeneration of damaged axons, in hopes of offering new insights for the repair of CNS injuries. |
| format | Article |
| id | doaj-art-9b94dcbcb0e54d388200348a6c6aee93 |
| institution | OA Journals |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-9b94dcbcb0e54d388200348a6c6aee932025-08-20T01:51:14ZengElsevierRegenerative Therapy2352-32042025-06-012949349810.1016/j.reth.2025.04.011Research status of regenerative difficulties after central nervous system injuryYunxia Fu0Xi Rui1Shumin Zhu2Chenqu Guo3Haoyang Li4Zhenhao Pan5Xuanhao Wu6Wenpeng He7School of Stomatology, Jinan University, Guangzhou 510632, ChinaHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China; School of Stomatology, Jinan University, Guangzhou 510632, ChinaHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China; School of Stomatology, Jinan University, Guangzhou 510632, ChinaSchool of Stomatology, Jinan University, Guangzhou 510632, ChinaSchool of Stomatology, Jinan University, Guangzhou 510632, ChinaSchool of Stomatology, Jinan University, Guangzhou 510632, ChinaSchool of Stomatology, Jinan University, Guangzhou 510632, ChinaHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China; School of Stomatology, Jinan University, Guangzhou 510632, China; Corresponding author. Hospital of stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.Multiple studies have shown that permanent functional disabilities caused after nerve damage are mainly due to the limited ability of damaged neurons in the central nervous system (CNS) to regenerate axons and re-establish functional connections. Most axons in the CNS of adult mammals cannot reactivate their intrinsic growth program after injury, making axonal regeneration difficult when damaged. This article provides a systematic review of the response processes following CNS injury and the factors affecting repair and regeneration, focusing on the molecular mechanisms that regulate the regeneration of damaged axons, in hopes of offering new insights for the repair of CNS injuries.http://www.sciencedirect.com/science/article/pii/S2352320425000872Central nerve injuryAxon regenerationMicrotubuleGlial scarsPTEN |
| spellingShingle | Yunxia Fu Xi Rui Shumin Zhu Chenqu Guo Haoyang Li Zhenhao Pan Xuanhao Wu Wenpeng He Research status of regenerative difficulties after central nervous system injury Regenerative Therapy Central nerve injury Axon regeneration Microtubule Glial scars PTEN |
| title | Research status of regenerative difficulties after central nervous system injury |
| title_full | Research status of regenerative difficulties after central nervous system injury |
| title_fullStr | Research status of regenerative difficulties after central nervous system injury |
| title_full_unstemmed | Research status of regenerative difficulties after central nervous system injury |
| title_short | Research status of regenerative difficulties after central nervous system injury |
| title_sort | research status of regenerative difficulties after central nervous system injury |
| topic | Central nerve injury Axon regeneration Microtubule Glial scars PTEN |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425000872 |
| work_keys_str_mv | AT yunxiafu researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury AT xirui researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury AT shuminzhu researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury AT chenquguo researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury AT haoyangli researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury AT zhenhaopan researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury AT xuanhaowu researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury AT wenpenghe researchstatusofregenerativedifficultiesaftercentralnervoussysteminjury |